Lago Aline Simone Dias do, Zaffarani Caroline, Mendonça Juliana Fernandes Barreto, Moran Cristiane Aparecida, Costa Dirceu, Gomes Evelim Leal de Freitas Dantas
Faculdade do Bico do Papagaio (FABIC)-Physiocursos, São Paulo, SP, Brazil.
Universidade Federal de Santa Catarina, (UFSC), Araranguá, SC, Brazil.
Hematol Transfus Cell Ther. 2021 Jul-Sep;43(3):313-323. doi: 10.1016/j.htct.2020.07.013. Epub 2020 Nov 8.
Hematopoietic stem cell transplantation (HSCT) is a treatment that requires long periods of hospitalization. The mobility restrictions result in physical, functional and psychological impairments. Physical exercise is a therapy that can restore physical and functional capacities; however, it is necessary to understand the effects of its practice in post-HSCT individuals. The purpose of this systematic review (SR) was to assess the impact of physical exercise in children and adolescents undergoing HSCT. The SR was conducted following the PRISMA guidelines through search in the electronic databases Embase, Lilacs, PEDro, PubMed and SCOPUS, without limitation of dates and languages. Randomized or non-randomized clinical trials with children and adolescents who underwent HSCT, aged between 3 to 19 years old, who participated in a regular physical activity program, were assessed. After removing duplicates and selecting studies according to the eligibility criteria, seven parallel studies incorporating hospitalized and discharged participants undertaking aerobic and strengthening exercises were included in this study. The main outcomes analyzed were exercise capacity, quality-of-life, body composition and freedom. Five studies comprised the meta-analysis regarding the effects of the distance walked in the 6-min walk test and quality-of-life. Physical exercise is considered to be safe, feasible and efficacious to prevent the decline of the quality-of-life in children and adolescents undergoing HCST, as well as a considerable improvement in physical capacity.
造血干细胞移植（HSCT）是一种需要长期住院治疗的方法。行动受限会导致身体、功能和心理方面的损害。体育锻炼是一种可以恢复身体和功能能力的疗法；然而，有必要了解其对造血干细胞移植后个体的影响。本系统评价（SR）的目的是评估体育锻炼对接受造血干细胞移植的儿童和青少年的影响。该系统评价按照PRISMA指南进行，通过在电子数据库Embase、Lilacs、PEDro、PubMed和SCOPUS中进行检索，不限日期和语言。对年龄在3至19岁之间、接受造血干细胞移植且参加了常规体育活动项目的儿童和青少年进行的随机或非随机临床试验进行了评估。在去除重复项并根据纳入标准选择研究后，本研究纳入了七项平行研究，这些研究纳入了住院和出院的参与者，他们进行了有氧运动和力量训练。分析的主要结果包括运动能力、生活质量、身体成分和活动能力。五项研究纳入了关于6分钟步行试验中步行距离的影响和生活质量的荟萃分析。体育锻炼被认为是安全、可行且有效的，可以防止接受造血干细胞移植的儿童和青少年生活质量下降，同时也能显著提高身体能力。
