Physicians Committee for Responsible Medicine, Washington, DC; George Washington University School of Medicine and Health Sciences, Washington, DC.
Physicians Committee for Responsible Medicine, Washington, DC.
J Acad Nutr Diet. 2021 Jun;121(6):1080-1086. doi: 10.1016/j.jand.2020.08.079. Epub 2020 Dec 4.
Risk of cardiovascular disease is lower in individuals with blood type O and increased in individuals with blood type A, compared with those in other blood groups. However, little evidence is available regarding whether individuals with different blood types benefit from different diet recommendations.
As part of a larger intervention trial using a low-fat vegan diet, this study ascertained whether changes in cardiometabolic outcomes were associated with ABO blood type.
A secondary analysis among intervention-group participants in a 16-week randomized clinical trial.
PARTICIPANTS/SETTING: In a larger study of overweight individuals randomly assigned to follow a low-fat vegan diet or to make no diet changes for 16 weeks, ABO blood typing was conducted on 68 intervention-group participants.
Intervention-group participants were asked to follow a low-fat vegan diet and attend weekly educational classes to aid in diet adherence.
Body weight, fat mass, visceral fat volume, blood lipid levels, fasting plasma glucose levels, and glycated hemoglobin concentrations.
Student t tests compared participants with blood type A to all other participants, and individuals with blood type O to all other participants.
There were no significant differences in any outcome between individuals of blood type A and all other participants, or between individuals of blood type O and all other participants. Mean body weight change was -5.7 kg for blood type A participants and -7.0 kg for all other participants (P = 0.09), and was -7.1 kg for type O participants and -6.2 kg for all other participants (P = 0.33). Mean total cholesterol decreased 17.2 mg/dL in the type A group and 18.3 mg/dL for all other participants (P = 0.90), and decreased 17.4 mg/dL among type O participants and 18.4 mg/dL for all other participants (P = 0.89).
Blood type was not associated with the effects of a plant-based diet on body weight, body fat, plasma lipid concentrations, or glycemic control.
与其他血型相比，O 型血个体的心血管疾病风险较低，而 A 型血个体的风险较高。然而，关于不同血型的个体是否受益于不同的饮食建议，目前几乎没有证据。
作为一项使用低脂纯素饮食的大型干预试验的一部分，本研究旨在确定心血管代谢结局的变化是否与 ABO 血型有关。
对一项为期 16 周的随机临床试验中干预组参与者的二次分析。
参与者/设置：在一项对超重个体的大型研究中，他们被随机分配遵循低脂纯素饮食或在 16 周内不改变饮食，对 68 名干预组参与者进行了 ABO 血型检测。
干预组参与者被要求遵循低脂纯素饮食，并参加每周的教育课程以帮助他们坚持饮食。
体重、体脂肪量、内脏脂肪量、血脂水平、空腹血糖水平和糖化血红蛋白浓度。
学生 t 检验比较了 A 型血参与者与所有其他参与者，以及 O 型血参与者与所有其他参与者之间的差异。
A 型血个体与所有其他参与者之间，以及 O 型血个体与所有其他参与者之间，在任何结果上均无显著差异。A 型血参与者的体重变化平均值为-5.7 公斤，而所有其他参与者为-7.0 公斤（P=0.09），O 型血参与者为-7.1 公斤，而所有其他参与者为-6.2 公斤（P=0.33）。A 型血组总胆固醇降低 17.2mg/dL，所有其他参与者降低 18.3mg/dL（P=0.90），O 型血组降低 17.4mg/dL，所有其他参与者降低 18.4mg/dL（P=0.89）。
血型与植物性饮食对体重、体脂肪、血浆脂质浓度或血糖控制的影响无关。
