缺氧和 CD11b+ 细胞浸润与口腔癌淋巴结转移密切相关。
Hypoxia and CD11b+ Cell Influx Are Strongly Associated With Lymph Node Metastasis of Oral Cancer.
机构信息
Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Life Science Dentistry, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan.
出版信息
Anticancer Res. 2020 Dec;40(12):6845-6852. doi: 10.21873/anticanres.14706.
BACKGROUND/AIM: Treatment failure in oral cancer is mainly caused by uncontrolled cervical lymph node (LN) metastasis. We previously reported that CD11b+ cells are recruited into tumor hypoxic areas following radiation, leading to re-vascularization and relapse. Since lymphatic vessel formation has similarities with vascular formation, we examined whether surgery induces hypoxia and stimulates lymphangiogenesis.
MATERIALS AND METHODS
The recruitment of CD11b+ cells and the formation of lymphatic vessels were examined using orthotopic tongue cancer mouse models with glossectomy.
RESULTS
Surgery on OSC-19 tumor induced LN metastases and hypoxia, followed by CD11b+ cell influx. These phenomena were not observed in the no tumor or SAT tumor models. Stimulation of lymphangiogenesis was observed in the CD11b+ cell influx area, as the tumor grew. The localization of CD11b+ cells was changed from the lymph nodules to the medullary sinuses.
CONCLUSION
Surgery-induced hypoxia in oral tumors leads to CD11b+ cell infiltration, lymphangiogenesis, and LN metastasis.
背景/目的：口腔癌治疗失败主要是由于颈部淋巴结（LN）转移失控所致。我们之前曾报道过，CD11b+细胞在接受放疗后会被招募到肿瘤缺氧区域，导致血管再生成和复发。由于淋巴管的形成与血管形成具有相似性，我们检查了手术是否会引起缺氧并刺激淋巴管生成。
材料和方法
使用带有舌癌的原位肿瘤小鼠模型进行了舌切除术，以检查 CD11b+细胞的募集和淋巴管的形成。
结果
OSC-19 肿瘤的手术会引起 LN 转移和缺氧，随后会有 CD11b+细胞的涌入。在没有肿瘤或 SAT 肿瘤的模型中没有观察到这些现象。随着肿瘤的生长，在 CD11b+细胞涌入的区域观察到了淋巴管生成的刺激。CD11b+细胞的定位从淋巴结转移到了髓窦。
结论
口腔肿瘤手术引起的缺氧会导致 CD11b+细胞浸润、淋巴管生成和 LN 转移。
Zotero 插件