Ali Ashaq, Rashid Zubia, Zhou Jieqiong, Zubair Yousaf Muhammad, Galani Saddia, Ashraf Asma, Al-Ghanim Khalid A, Al-Suliman Emin, Ahmed Zubair, Farooq Muhammad, Virik Promy, Kaimkhani Z A, Al-Mulhm Norah, Mahboob Shahid, Dong Men, Huang Qiuxiang
State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
J King Saud Univ Sci. 2021 Jan;33(1):101255. doi: 10.1016/j.jksus.2020.101255. Epub 2020 Dec 2.
The ongoing SARS-CoV-2 pandemic infecting millions of people globally has given rise to serious public health threats. The need for early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic pregnant women is compelling to detect vertical transmission timely. Here, 11 SARS-CoV-2 asymptomatic pregnant cases from Wuhan China were investigated. All the patients were initially tested negative for SARS-CoV-2 on RT-PCR, so a chest CT scan was performed. Also, serum antibody (IgM and IgG) titers were estimated. CT scan of patients revealed typical abnormalities related to SARS-CoV-2, indicating ground-glass opacity and infection lesions suggesting viral pneumonia. Elevated IgM and IgG antibodies levels () were also noticed in infected patients. Hence, CT imaging and serum antibody response are valuable in the early detection of SARS-CoV-2 in asymptomatic pregnant patients. These might serve as prognostic markers for healthcare professionals, in RT-PCR negative patients, to assess the effect of given treatment by chest CT.
持续的新型冠状病毒肺炎大流行在全球感染了数百万人，带来了严重的公共卫生威胁。及时检测无症状孕妇中的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）以发现垂直传播的需求迫在眉睫。在此，对来自中国武汉的11例无症状感染SARS-CoV-2的孕妇病例进行了调查。所有患者最初的逆转录聚合酶链反应（RT-PCR）检测结果均为SARS-CoV-2阴性，因此进行了胸部CT扫描。此外，还测定了血清抗体（IgM和IgG）滴度。患者的CT扫描显示出与SARS-CoV-2相关的典型异常，表现为磨玻璃影和提示病毒性肺炎的感染性病变。在感染患者中也观察到IgM和IgG抗体水平升高。因此，CT成像和血清抗体反应对于无症状孕妇中SARS-CoV-2的早期检测具有重要价值。对于医护人员而言，在RT-PCR检测呈阴性的患者中，这些结果可能作为预后指标，用于通过胸部CT评估特定治疗的效果。
