Makhov V M, Ugriumova L N, Gitel' E P, Struchkova T Ia, Savchenko L M
Ter Arkh. 1987;59(12):68-71.
The results of puncture biopsy of the liver, ultrasonic and angiographic investigation of the liver and pancreas in 114 patients with chronic alcoholism revealed an increment of changes in these organs in parallel with an increase in the duration of chronic alcoholic intoxication. A simultaneous study of immunoreactive insulin (IRI) and C-peptide showed that an increase in the IRI basal level in the patients suffering from alcoholism up to 10 yrs was determined mainly by an increase in the activity of beta-cells. In a long period of alcoholism an increase in the IRI basal level resulted from a decrease in the rate of insulin degradation in the liver as assessed by a lower level of C-peptide. In liver cirrhosis a noticeable decrease in pancreatic incretory function was combined with noticeable disturbance of insulin degradation in the liver. The above investigations showed that there were morphological, functional and clinical signs of the "hepatopancreatic syndrome" in chronic alcoholism.
对114例慢性酒精中毒患者进行肝脏穿刺活检、肝脏及胰腺超声和血管造影检查的结果显示，这些器官的病变随着慢性酒精中毒持续时间的增加而增多。对免疫反应性胰岛素（IRI）和C肽的同步研究表明，酗酒10年以内患者IRI基础水平的升高主要由β细胞活性增加所致。在长期酗酒过程中，根据C肽水平降低评估，IRI基础水平的升高是由于肝脏中胰岛素降解速率降低所致。在肝硬化时，胰腺内分泌功能明显降低，同时肝脏中胰岛素降解明显紊乱。上述研究表明，慢性酒精中毒存在“肝胰综合征”的形态学、功能和临床征象。
