Angle Orthod. 2021 Mar 1;91(2):206-212. doi: 10.2319/041320-296.1.
To determine if the depth of corticotomy done with the piezoelectric knife could play a role in the intensity of the regional acceleratory phenomenon (RAP).
Eighteen Sprague-Dawley rats were divided into two groups: untreated (3 rats) and treatment (15 rats). In the treatment group, a split-model design was used. The right tibia received transcortical (deep) penetrations with the piezoelectric knife, while intracortical (shallow) penetrations were performed on the left tibia of the same animal. The rats were euthanized at day 1, 3, 7, 14, and 28. Cone-beam computed tomography scans were taken for each sample and then assessed by histological analysis.
Higher amounts of osteoclastic activity and new collagen formation were observed in the deep penetration group when compared with the shallow penetration group. The former peaked at day 14 for both groups (1.53% ± 0.01% vs 0.03% ± 0.0004%, respectively), and the latter peaked at day 28 (0.65 × 106 ± 0.01 vs 0.08 × 106 ± 0.0008, respectively).
Within the limitations of this study, it appears that the intensity of the RAP in the rat is corticotomy depth dependent. This is to be kept in mind when decorticating the bone during surgically facilitated orthodontic procedures.
确定使用压电刀进行的皮质切开术的深度是否会影响区域加速现象（RAP）的强度。
将 18 只 Sprague-Dawley 大鼠分为两组：未处理组（3 只）和处理组（15 只）。在处理组中，采用分割模型设计。右胫骨用压电刀进行皮质下（深）穿透，而同一动物的左胫骨进行皮质内（浅）穿透。大鼠在第 1、3、7、14 和 28 天处死。对每个样本进行锥形束计算机断层扫描，并通过组织学分析进行评估。
与浅穿透组相比，深穿透组的破骨细胞活性和新胶原形成明显增加。两组均在第 14 天达到峰值（分别为 1.53%±0.01%和 0.03%±0.0004%），后者在第 28 天达到峰值（分别为 0.65×106±0.01 和 0.08×106±0.0008）。
在本研究的限制范围内，似乎大鼠的 RAP 强度与皮质切开术的深度有关。在手术辅助正畸过程中对骨进行去皮质时应牢记这一点。
