皮肤肿瘤的神经内分泌分化：全面综述

Neuroendocrine Differentiation of Skin Tumors: A Comprehensive Review.

作者信息

Hamie Lamiaa, Abbas Ossama, Bhawan Jag

机构信息

Dermatology Resident, Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.

Professor, Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon; and.

出版信息

Am J Dermatopathol. 2020 Dec;42(12):899-910. doi: 10.1097/DAD.0000000000001664.

DOI:10.1097/DAD.0000000000001664

PMID:33289975

Abstract

Neuroendocrine differentiation is characterized by endocrine and neuronal features with prominent dense secretory granules and neuropeptides. Neuroendocrine differentiation of skin tumors is of unknown clinical significance. Nonetheless, the acknowledgment of this line of differentiation is important to prevent diagnostic pitfalls and subsequent inappropriate management. This review aims at summarizing the skin neoplasms that can express neuroendocrine markers.

摘要

神经内分泌分化的特征是具有突出的致密分泌颗粒和神经肽的内分泌及神经元特征。皮肤肿瘤的神经内分泌分化的临床意义尚不清楚。尽管如此，认识到这种分化类型对于防止诊断失误及后续不恰当的处理很重要。本综述旨在总结可表达神经内分泌标志物的皮肤肿瘤。