Yoon Woohyuk, Lee Jong Im, Lee Joon Ho
Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.
Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea.
Arch Craniofac Surg. 2025 Feb;26(1):38-42. doi: 10.7181/acfs.2025.00661. Epub 2025 Feb 20.
Neuroendocrine carcinoma (NEC) is a rare aggressive tumor of the skin with a shared phenotype of both endocrine and neuronal features. Its behavior includes rapid progression, common local recurrence, frequent metastasis to local lymph nodes, and occasional systematic involvement. The risk factors for NEC are similar to those for other skin cancers and mainly include ultraviolet light exposure, older age, T-cell immunosuppression, fair skin, and male sex. NEC is seen more frequently in the immunosuppressed population, and we report a rare case of NEC combined with squamous cell carcinoma (SCC) in a patient who underwent kidney transplantation. A 66-year-old man was referred with a brownish plaque on left cheek, and a punch biopsy result indicated SCC in situ. Wide excision was performed, and the defect was reconstructed using a bilobed flap. The final biopsy confirmed SCC combined with carcinoma with neuroendocrine differentiation, and positron emission tomography-computed tomography confirmed the absence of lymph node metastasis or systemic involvement. The patient showed no evidence of recurrence or other postoperative complications.
神经内分泌癌（NEC）是一种罕见的侵袭性皮肤肿瘤，具有内分泌和神经特征的共同表型。其行为包括快速进展、常见的局部复发、频繁转移至局部淋巴结以及偶尔的全身累及。NEC的危险因素与其他皮肤癌相似，主要包括紫外线暴露、年龄较大、T细胞免疫抑制、皮肤白皙和男性。NEC在免疫抑制人群中更常见，我们报告了一例肾移植患者中罕见的NEC合并鳞状细胞癌（SCC）病例。一名66岁男性因左脸颊出现褐色斑块前来就诊，穿刺活检结果显示原位SCC。进行了广泛切除，并使用双叶皮瓣修复缺损。最终活检证实为SCC合并神经内分泌分化癌，正电子发射断层扫描-计算机断层扫描证实无淋巴结转移或全身累及。患者无复发或其他术后并发症的迹象。
