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在胰腺腺癌中 和 基因簇的表达模式和预后价值。

Expression patterns and prognostic values of the and gene cluster in pancreatic adenocarcinoma.

机构信息

Department of Gastroenterology, The Central Hospital of Weihai, Weihai, Shandong, China.

Hepatobiliary Surgery Department, Shandong Provincial Third Hospital, Jinan, Shandong, China.

出版信息

J Int Med Res. 2020 Dec;48(12):300060520930113. doi: 10.1177/0300060520930113.

DOI:10.1177/0300060520930113
PMID:33290118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7727076/
Abstract

OBJECTIVE

Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignant tumors worldwide. Various studies based on cell lines, preclinical mouse models, and human tissue samples have shown that cell cycle-associated proteins are involved in the tumorigenesis and progression of PAAD.

METHODS

Herein, we analyzed the relationships between and gene expression and prognosis in patients with pancreatic cancer, using information from the Oncomine, cBioportal, Kaplan-Meier Plotter, and GEPIA databases.

RESULTS

Expression levels of and were significantly higher in PAAD compared with control tissues, and were associated with more advanced tumor stage. Survival analyses using the Kaplan-Meier Plotter database further confirmed that increased expression levels of and were associated with a poor prognosis in patients with pancreatic cancer.

CONCLUSIONS

The results of this study suggest that CDK1 and CCNA2 may be potential therapeutic targets and prognostic biomarkers in patients with PAAD.

摘要

目的

胰腺导管腺癌（PAAD）是全球最致命的恶性肿瘤之一。基于细胞系、临床前小鼠模型和人体组织样本的各种研究表明，细胞周期相关蛋白参与了 PAAD 的发生和发展。

方法

本研究利用 Oncomine、cBioportal、Kaplan-Meier Plotter 和 GEPIA 数据库的信息，分析了 CDK1 和 CCNA2 基因表达与胰腺癌患者预后之间的关系。

结果

与对照组织相比，PAAD 中 CDK1 和 CCNA2 的表达水平显著升高，并且与更晚期的肿瘤分期相关。Kaplan-Meier Plotter 数据库的生存分析进一步证实，CDK1 和 CCNA2 的高表达与胰腺癌患者的预后不良相关。

结论

本研究结果表明，CDK1 和 CCNA2 可能是 PAAD 患者潜在的治疗靶点和预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/b6554801d4b3/10.1177_0300060520930113-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/dd0995932449/10.1177_0300060520930113-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/589b6e231bad/10.1177_0300060520930113-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/4d6e2f45b6ed/10.1177_0300060520930113-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/2043aa0c82c1/10.1177_0300060520930113-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/2df66d8c1bdc/10.1177_0300060520930113-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/04cc5e743739/10.1177_0300060520930113-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/b6554801d4b3/10.1177_0300060520930113-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/dd0995932449/10.1177_0300060520930113-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/589b6e231bad/10.1177_0300060520930113-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/4d6e2f45b6ed/10.1177_0300060520930113-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/2043aa0c82c1/10.1177_0300060520930113-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/2df66d8c1bdc/10.1177_0300060520930113-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/04cc5e743739/10.1177_0300060520930113-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1897/7727076/b6554801d4b3/10.1177_0300060520930113-fig7.jpg

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2
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3
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