• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人乳腺癌中 、 和 基因簇的表达及预后价值 。 （原文中未明确给出具体基因名称，用“ ”代替）

Expression and prognostic value of , , and gene clusters in human breast cancer.

作者信息

Xing Zeyu, Wang Xin, Liu Jiaqi, Zhang Menglu, Feng Kexin, Wang Xiang

机构信息

Breast Cancer Department, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

J Int Med Res. 2021 Apr;49(4):300060520980647. doi: 10.1177/0300060520980647.

DOI:10.1177/0300060520980647
PMID:33896262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8076779/
Abstract

OBJECTIVE

Cell cycle-associated proteins play important roles in breast cancer (BRCA), based on evidence from cell lines, preclinical murine models, and human tissue samples.

METHODS

Herein, we used the Onomine, GEPIA, Kaplan-Meier Plotter, and cBioPortal databases to examine transcriptional and survival data pertaining to cyclin-associated gene clusters (, , and ) in BRCA patients.

RESULTS

, , and gene expression levels were higher in BRCA compared with control tissue samples and were correlated with more-advanced tumor stage. Kaplan-Meier survival analyses confirmed that elevated , , and expression levels were associated with overall and post-progression survival and recurrence-free probability rates in patients with BRCA.

CONCLUSION

The results of this study implied that , , and gene clusters may provide potential therapeutic targets and prognostic biomarkers in patients with BRCA.

摘要

目的

基于细胞系、临床前小鼠模型及人体组织样本的证据，细胞周期相关蛋白在乳腺癌（BRCA）中发挥重要作用。

方法

在此，我们使用Onomine、GEPIA、Kaplan-Meier Plotter和cBioPortal数据库来检查与BRCA患者中细胞周期蛋白相关基因簇（、和）有关的转录和生存数据。

结果

与对照组织样本相比，BRCA中、和基因表达水平更高，且与更晚期肿瘤分期相关。Kaplan-Meier生存分析证实，、和表达水平升高与BRCA患者的总生存、进展后生存及无复发生存概率相关。

结论

本研究结果表明，、和基因簇可能为BRCA患者提供潜在的治疗靶点和预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/8197102af37c/10.1177_0300060520980647-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/9a5041b7b8d3/10.1177_0300060520980647-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/fac730ce8fde/10.1177_0300060520980647-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/b2390a9ce05b/10.1177_0300060520980647-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/ca03ee79d8cf/10.1177_0300060520980647-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/746bc7e4a525/10.1177_0300060520980647-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/0bf48bdbb9e3/10.1177_0300060520980647-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/8197102af37c/10.1177_0300060520980647-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/9a5041b7b8d3/10.1177_0300060520980647-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/fac730ce8fde/10.1177_0300060520980647-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/b2390a9ce05b/10.1177_0300060520980647-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/ca03ee79d8cf/10.1177_0300060520980647-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/746bc7e4a525/10.1177_0300060520980647-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/0bf48bdbb9e3/10.1177_0300060520980647-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c42/8076779/8197102af37c/10.1177_0300060520980647-fig7.jpg

相似文献

1
Expression and prognostic value of , , and gene clusters in human breast cancer.人乳腺癌中 、 和 基因簇的表达及预后价值 。 （原文中未明确给出具体基因名称，用“ ”代替）
J Int Med Res. 2021 Apr;49(4):300060520980647. doi: 10.1177/0300060520980647.
2
Upregulated cyclins may be novel genes for triple-negative breast cancer based on bioinformatic analysis.基于生物信息学分析，上调的细胞周期蛋白可能是三阴性乳腺癌的新基因。
Breast Cancer. 2020 Sep;27(5):903-911. doi: 10.1007/s12282-020-01086-z. Epub 2020 Apr 27.
3
Expression patterns and prognostic values of the and gene cluster in pancreatic adenocarcinoma.在胰腺腺癌中 和 基因簇的表达模式和预后价值。
J Int Med Res. 2020 Dec;48(12):300060520930113. doi: 10.1177/0300060520930113.
4
Expression of KIF2A, NDC80, CDK1, and CCNB1 in breast cancer patients: Their interaction and linkage with tumor features and prognosis.KIF2A、NDC80、CDK1 和 CCNB1 在乳腺癌患者中的表达：它们与肿瘤特征和预后的相互作用和关联。
J Clin Lab Anal. 2022 Sep;36(9):e24647. doi: 10.1002/jcla.24647. Epub 2022 Aug 10.
5
Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma.肿瘤组织中 BUB1B、CCNA2、CDC20 和 CDK1 的过表达预示着胰腺导管腺癌患者的预后不良。
Biosci Rep. 2019 Feb 26;39(2). doi: 10.1042/BSR20182306. Print 2019 Feb 28.
6
CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma.CDK1、CCNB1 和 CCNB2 是肝癌的预后生物标志物，并与免疫浸润相关。
Med Sci Monit. 2020 Aug 31;26:e925289. doi: 10.12659/MSM.925289.
7
[CDK1, CCNB1 and NDC80 are associated with prognosis and progression of hepatitis B virus-associated hepatocellular carcinoma: a bioinformatic analysis].[细胞周期蛋白依赖性激酶1、细胞周期蛋白B1和NDC80与乙型肝炎病毒相关肝细胞癌的预后和进展相关：一项生物信息学分析]
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Oct 20;41(10):1509-1518. doi: 10.12122/j.issn.1673-4254.2021.10.09.
8
Identification of key molecular markers in epithelial ovarian cancer by integrated bioinformatics analysis.整合生物信息学分析鉴定上皮性卵巢癌的关键分子标志物。
Taiwan J Obstet Gynecol. 2021 Nov;60(6):983-994. doi: 10.1016/j.tjog.2021.09.007.
9
CDK1 and CCNB1 as potential diagnostic markers of rhabdomyosarcoma: validation following bioinformatics analysis.CDK1 和 CCNB1 作为横纹肌肉瘤的潜在诊断标志物：基于生物信息学分析的验证。
BMC Med Genomics. 2019 Dec 23;12(1):198. doi: 10.1186/s12920-019-0645-x.
10
Bioinformatical Analysis of Gene Expression Omnibus Database Associates TAF7/CCNB1, TAF7/CCNA2, and GTF2E2/CDC20 Pathways with Glioblastoma Development and Prognosis.基于基因表达综合数据库的生物信息学分析提示 TAF7/CCNB1、TAF7/CCNA2 和 GTF2E2/CDC20 通路与胶质母细胞瘤的发生发展和预后相关。
World Neurosurg. 2020 Jun;138:e492-e514. doi: 10.1016/j.wneu.2020.02.159. Epub 2020 Mar 5.

引用本文的文献

1
Data-Driven Discovery of a Key Regulator Cyclin A2 as a Promising Therapeutic Target in Hormone-Sensitive Cancers.数据驱动发现关键调节因子细胞周期蛋白A2作为激素敏感性癌症中有前景的治疗靶点
Mol Biotechnol. 2025 Sep 11. doi: 10.1007/s12033-025-01504-7.
2
Investigating the molecular mechanisms, drug prediction, and validation of CCNA2 and MAD2L1 in esophageal squamous cell carcinoma based on bioinformatics.基于生物信息学研究CCNA2和MAD2L1在食管鳞状细胞癌中的分子机制、药物预测及验证
BMC Med Genomics. 2025 Jul 1;18(1):107. doi: 10.1186/s12920-025-02173-w.
3
Cyclin A2 Induces Human Adult Cardiomyocyte Cytokinesis and Elicits Cardiomyocyte Reprogramming and Dedifferentiation.

本文引用的文献

1
Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27.Myc 通过激活 Cdk1 和磷酸化 p27 来刺激细胞周期进程。
Sci Rep. 2019 Dec 10;9(1):18693. doi: 10.1038/s41598-019-54917-1.
2
HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferation and metastasis.异质性核糖核蛋白R-细胞周期蛋白B1/着丝粒蛋白F轴促进胃癌的增殖和转移。
Aging (Albany NY). 2019 Sep 16;11(18):7473-7491. doi: 10.18632/aging.102254.
3
Effect of hyperoside on cervical cancer cells and transcriptome analysis of differentially expressed genes.
细胞周期蛋白A2诱导人类成年心肌细胞胞质分裂并引发心肌细胞重编程和去分化。
Res Sq. 2025 May 15:rs.3.rs-6597490. doi: 10.21203/rs.3.rs-6597490/v1.
4
Transcriptomic Profiling Reveals Altered Expression of Genes Involved in Metabolic and Immune Processes in NDV-Infected Chicken Embryos.转录组分析揭示了新城疫病毒感染鸡胚中参与代谢和免疫过程的基因表达变化。
Metabolites. 2024 Dec 2;14(12):669. doi: 10.3390/metabo14120669.
5
Combining serum CDK1 with tumor markers for the diagnosis of small cell lung cancer.联合血清细胞周期蛋白依赖性激酶1与肿瘤标志物用于小细胞肺癌的诊断。
Clin Transl Oncol. 2025 May;27(5):2005-2013. doi: 10.1007/s12094-024-03722-y. Epub 2024 Oct 13.
6
Nearby and non-nested genes in the human genome have more similar genotype tissue expression.人类基因组中附近且非嵌套的基因具有更相似的基因型组织表达。
PLoS One. 2024 Sep 18;19(9):e0307360. doi: 10.1371/journal.pone.0307360. eCollection 2024.
7
A Multi-Omics Study of Epigenetic Changes in Type II Alveolar Cells of A/J Mice Exposed to Environmental Tobacco Smoke.环境烟草烟雾暴露的 A/J 型 II 型肺泡细胞的表观遗传学变化的多组学研究。
Int J Mol Sci. 2024 Aug 29;25(17):9365. doi: 10.3390/ijms25179365.
8
DriverMP enables improved identification of cancer driver genes.DriverMP 可提高癌症驱动基因的识别能力。
Gigascience. 2022 Dec 28;12. doi: 10.1093/gigascience/giad106. Epub 2023 Dec 13.
9
The Cyclin-dependent kinase 1: more than a cell cycle regulator.细胞周期蛋白依赖性激酶 1：不仅仅是细胞周期调控因子。
Br J Cancer. 2023 Nov;129(11):1707-1716. doi: 10.1038/s41416-023-02468-8. Epub 2023 Oct 28.
10
A pancancer analysis of the oncogenic role of cyclin B1 (CCNB1) in human tumors.泛癌症分析 cyclin B1（CCNB1）在人类肿瘤中的致癌作用。
Sci Rep. 2023 Sep 27;13(1):16226. doi: 10.1038/s41598-023-42801-y.
金丝桃苷对宫颈癌细胞的影响及差异表达基因的转录组分析
Cancer Cell Int. 2019 Sep 9;19:235. doi: 10.1186/s12935-019-0953-4. eCollection 2019.
4
CCNA2 acts as a novel biomarker in regulating the growth and apoptosis of colorectal cancer.CCNA2作为一种新型生物标志物，在调节结直肠癌的生长和凋亡中发挥作用。
Cancer Manag Res. 2018 Oct 31;10:5113-5124. doi: 10.2147/CMAR.S176833. eCollection 2018.
5
Polyclonal RB1 mutations and acquired resistance to CDK 4/6 inhibitors in patients with metastatic breast cancer.多克隆 RB1 突变与转移性乳腺癌患者对 CDK4/6 抑制剂获得性耐药。
Ann Oncol. 2018 Mar 1;29(3):640-645. doi: 10.1093/annonc/mdx784.
6
Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.靶向 CDK1 和 MEK/ERK 克服 BRAF 突变型人结直肠癌的凋亡抵抗。
Mol Cancer Res. 2018 Mar;16(3):378-389. doi: 10.1158/1541-7786.MCR-17-0404. Epub 2017 Dec 12.
7
MiR-181a inhibits non-small cell lung cancer cell proliferation by targeting CDK1.miR-181a 通过靶向 CDK1 抑制非小细胞肺癌细胞增殖。
Cancer Biomark. 2017 Dec 6;20(4):539-546. doi: 10.3233/CBM-170350.
8
Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer.曲妥珠单抗-美坦新（T-DM1）获得性耐药的 HER2 阳性乳腺癌中细胞周期蛋白 B1 缺陷的诱导。
Clin Cancer Res. 2017 Nov 15;23(22):7006-7019. doi: 10.1158/1078-0432.CCR-17-0696. Epub 2017 Aug 18.
9
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.GEPIA：一个用于癌症和正常基因表达谱分析及交互式分析的网络服务器。
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102. doi: 10.1093/nar/gkx247.
10
Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer.长链非编码RNA ZFAS1与细胞周期蛋白依赖性激酶1相互作用，并参与结直肠癌中p53依赖的细胞周期调控和细胞凋亡。
Oncotarget. 2016 Jan 5;7(1):622-37. doi: 10.18632/oncotarget.5807.