人乳腺癌中 、 和 基因簇的表达及预后价值 。 （原文中未明确给出具体基因名称，用“ ”代替）
Expression and prognostic value of , , and gene clusters in human breast cancer.
作者信息
Xing Zeyu, Wang Xin, Liu Jiaqi, Zhang Menglu, Feng Kexin, Wang Xiang
机构信息
Breast Cancer Department, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
J Int Med Res. 2021 Apr;49(4):300060520980647. doi: 10.1177/0300060520980647.
OBJECTIVE
Cell cycle-associated proteins play important roles in breast cancer (BRCA), based on evidence from cell lines, preclinical murine models, and human tissue samples.
METHODS
Herein, we used the Onomine, GEPIA, Kaplan-Meier Plotter, and cBioPortal databases to examine transcriptional and survival data pertaining to cyclin-associated gene clusters (, , and ) in BRCA patients.
RESULTS
, , and gene expression levels were higher in BRCA compared with control tissue samples and were correlated with more-advanced tumor stage. Kaplan-Meier survival analyses confirmed that elevated , , and expression levels were associated with overall and post-progression survival and recurrence-free probability rates in patients with BRCA.
CONCLUSION
The results of this study implied that , , and gene clusters may provide potential therapeutic targets and prognostic biomarkers in patients with BRCA.
目的
基于细胞系、临床前小鼠模型及人体组织样本的证据，细胞周期相关蛋白在乳腺癌（BRCA）中发挥重要作用。
方法
在此，我们使用Onomine、GEPIA、Kaplan-Meier Plotter和cBioPortal数据库来检查与BRCA患者中细胞周期蛋白相关基因簇（、和）有关的转录和生存数据。
结果
与对照组织样本相比，BRCA中、和基因表达水平更高，且与更晚期肿瘤分期相关。Kaplan-Meier生存分析证实，、和表达水平升高与BRCA患者的总生存、进展后生存及无复发生存概率相关。
结论
本研究结果表明，、和基因簇可能为BRCA患者提供潜在的治疗靶点和预后生物标志物。
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