CDK1 和 BUB1 的高表达预示着胰腺导管腺癌预后不良。

High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma.

机构信息

Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, China; Key Laboratory of the Science and Technology Department of Jilin Province, Yanji 133002, China.

Department of Dermatology, Yanbian University Hospital, Yanji 133000, China.

出版信息

Gene. 2019 Jun 15;701:15-22. doi: 10.1016/j.gene.2019.02.081. Epub 2019 Mar 18.

DOI:10.1016/j.gene.2019.02.081

PMID:30898709

Abstract

BACKGROUND

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death. Increasing evidence suggests that cell cycle dysregulation is one of the hallmarks of cancer. In this study, by using the GEO database, we predicted the cell cycle-related protein CDK1 and BUB1 to be significantly overexpressed in PDAC tissues. Thus, this study aimed to investigate the clinical pathological significance of CDK1 and BUB1 in PDAC.

METHODS

To explore the role of CDK1 and BUB1 in PDAC progression and evaluate their prognostic value, we investigated the expression patterns of CDK1 and BUB1 by using immunohistochemical staining in 99 PDAC and 71 normal pancreatic tissues with complete pathological parameters and survival data.

RESULTS

CDK1 and BUB1 were significantly overexpressed in PDAC tissues. The expression of CDK1 was correlated with tumor size and histological grade, and the expression of BUB1 was correlated with the tumor size of PDAC. With regard to survival, a high expression of either CDK1 or BUB1 was correlated with a short survival of PDAC patients. Additionally, PDAC patients with a concurrent high expression of CDK1 and BUB1 showed the shortest survival.

CONCLUSIONS

Our study demonstrated that CDK1 and BUB1 may play a role in PDAC progression and could be prognostic biomarkers for PDAC patients.

摘要

背景

胰腺导管腺癌（PDAC）是癌症相关死亡的最常见原因之一。越来越多的证据表明，细胞周期失调是癌症的标志之一。在这项研究中，我们通过使用 GEO 数据库，预测细胞周期相关蛋白 CDK1 和 BUB1 在 PDAC 组织中显著过表达。因此，本研究旨在探讨 CDK1 和 BUB1 在 PDAC 中的临床病理意义。

方法

为了探讨 CDK1 和 BUB1 在 PDAC 进展中的作用并评估其预后价值，我们使用免疫组织化学染色法检测了 99 例 PDAC 组织和 71 例具有完整病理参数和生存数据的正常胰腺组织中 CDK1 和 BUB1 的表达模式。

结果

CDK1 和 BUB1 在 PDAC 组织中显著过表达。CDK1 的表达与肿瘤大小和组织学分级相关，而 BUB1 的表达与 PDAC 的肿瘤大小相关。就生存而言，CDK1 或 BUB1 的高表达与 PDAC 患者的短生存期相关。此外，同时高表达 CDK1 和 BUB1 的 PDAC 患者的生存期最短。