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先天性布鲁氏菌病:病例报告。

Congenital brucellosis: A case report.

机构信息

Clinical Pharmacy Department, King Saud Medical City, Riyadh, Saudi Arabia.

College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.

出版信息

J Int Med Res. 2020 Dec;48(12):300060520975576. doi: 10.1177/0300060520975576.

Abstract

Although rare, brucellosis is endemic in the Kingdom of Saudi Arabia (KSA). In the case presented here, a neonate was born at 29 weeks gestation with severe respiratory depression, pyrexia; hypotension and an elevated white blood cell count. Her mother was a 19-year-old pregnant woman who developed premature rupture of the membranes and went into labour early. Sepsis was suspected and so the neonate received dobutamine and empiric ampicillin/gentamicin. The mother reported visiting a farm during her pregnancy and so congenital brucellosis was considered a possibility. Blood cultures were positive for Gram-negative coccobacilli and serology confirmed the presence of and Antibiotic treatment was changed to rifampin/gentamicin/ciprofloxacin but on day 17 the baby deteriorated and gentamicin was discontinued and meropenem was added. The neonate gradually improved; meropenem was discontinued on day 24 and the baby was discharged from hospital on day 38.

摘要

布鲁氏菌病虽然罕见,但在沙特阿拉伯王国(KSA)却流行。在本例中,一名新生儿于 29 周胎龄出生,出现严重呼吸抑制、发热、低血压和白细胞计数升高。她的母亲是一名 19 岁的孕妇,胎膜早破并早产。怀疑发生了败血症,因此新生儿接受了多巴酚丁胺和经验性氨苄西林/庆大霉素治疗。母亲报告在怀孕期间曾去过一个农场,因此考虑存在先天性布鲁氏菌病的可能。血培养阳性为革兰氏阴性球杆菌,血清学检查证实存在 和 。抗生素治疗改为利福平/庆大霉素/环丙沙星,但在第 17 天,婴儿病情恶化,停用庆大霉素并加用美罗培南。新生儿逐渐好转;第 24 天停用美罗培南,第 38 天婴儿出院。

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本文引用的文献

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Laboratory Diagnosis of Human Brucellosis.人布鲁氏菌病的实验室诊断。
Clin Microbiol Rev. 2019 Nov 13;33(1). doi: 10.1128/CMR.00073-19. Print 2019 Dec 18.
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Congenital Brucellosis: A Systematic Review of the Literature.先天性布鲁氏菌病:文献系统综述
Vector Borne Zoonotic Dis. 2018 Aug;18(8):393-403. doi: 10.1089/vbz.2018.2280. Epub 2018 Jun 29.
6
Neonatal brucellosis: A case report.新生儿布鲁氏菌病:一例报告。
J Infect Dev Ctries. 2017 Feb 28;11(2):199-202. doi: 10.3855/jidc.8938.
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Pregnancy associated brucellosis.妊娠相关性布鲁氏菌病
Recent Pat Antiinfect Drug Discov. 2013 Apr;8(1):47-50. doi: 10.2174/1574891x11308010009.
8
Brucellosis in pregnancy.孕期布鲁氏菌病
Trop Doct. 2011 Apr;41(2):82-4. doi: 10.1258/td.2011.100386. Epub 2011 Mar 4.
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The new global map of human brucellosis.人类布鲁氏菌病的新全球地图。
Lancet Infect Dis. 2006 Feb;6(2):91-9. doi: 10.1016/S1473-3099(06)70382-6.

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