Clinical Pharmacy Department, King Saud Medical City, Riyadh, Saudi Arabia.
College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
J Int Med Res. 2020 Dec;48(12):300060520975576. doi: 10.1177/0300060520975576.
Although rare, brucellosis is endemic in the Kingdom of Saudi Arabia (KSA). In the case presented here, a neonate was born at 29 weeks gestation with severe respiratory depression, pyrexia; hypotension and an elevated white blood cell count. Her mother was a 19-year-old pregnant woman who developed premature rupture of the membranes and went into labour early. Sepsis was suspected and so the neonate received dobutamine and empiric ampicillin/gentamicin. The mother reported visiting a farm during her pregnancy and so congenital brucellosis was considered a possibility. Blood cultures were positive for Gram-negative coccobacilli and serology confirmed the presence of and Antibiotic treatment was changed to rifampin/gentamicin/ciprofloxacin but on day 17 the baby deteriorated and gentamicin was discontinued and meropenem was added. The neonate gradually improved; meropenem was discontinued on day 24 and the baby was discharged from hospital on day 38.
布鲁氏菌病虽然罕见，但在沙特阿拉伯王国（KSA）却流行。在本例中，一名新生儿于 29 周胎龄出生，出现严重呼吸抑制、发热、低血压和白细胞计数升高。她的母亲是一名 19 岁的孕妇，胎膜早破并早产。怀疑发生了败血症，因此新生儿接受了多巴酚丁胺和经验性氨苄西林/庆大霉素治疗。母亲报告在怀孕期间曾去过一个农场，因此考虑存在先天性布鲁氏菌病的可能。血培养阳性为革兰氏阴性球杆菌，血清学检查证实存在 和 。抗生素治疗改为利福平/庆大霉素/环丙沙星，但在第 17 天，婴儿病情恶化，停用庆大霉素并加用美罗培南。新生儿逐渐好转；第 24 天停用美罗培南，第 38 天婴儿出院。
