Gulsun Serda, Aslan Selda, Satici Omer, Gul Talip
Department of Infectious Diseases and Clinical Microbiology, Diyarbakir State Hospital, Diyarbakir, Turkey.
Trop Doct. 2011 Apr;41(2):82-4. doi: 10.1258/td.2011.100386. Epub 2011 Mar 4.
This study was undertaken in order to evaluate the effect of brucellosis in pregnancy. The serum agglutination test, Coombs and/or blood culture systems were used in the diagnosis of brucellosis. From July 2003 to September 2010, the clinical and delivery patterns of 40 healthy pregnant women were compared with 39 pregnant women who had brucellosis. There were no birth defects, anomalies or mortalities. We observed that brucellosis in pregnancy increases the incidence of preterm delivery (P = 0.01) and low birth weight (P = 0.001) from that seen in general deliveries. A cephtriaxone/rifampicin combination was found to be the most effective treatment in pregnant women infected with brucellosis (P = 0.004). Brucellosis in pregnancy has no effect on the incidence of congenital malformations or stillbirths. Preterm delivery and low birth weight can be seen as pregnancy outcomes in brucellosis. Appropriate antimicrobial therapy of brucellosis in pregnancy will reduce morbidity and prevent complications.
本研究旨在评估孕期布鲁氏菌病的影响。血清凝集试验、库姆斯试验和/或血培养系统用于布鲁氏菌病的诊断。2003年7月至2010年9月，将40名健康孕妇的临床和分娩模式与39名患有布鲁氏菌病的孕妇进行了比较。未出现出生缺陷、畸形或死亡情况。我们观察到，孕期布鲁氏菌病会使早产发生率（P = 0.01）和低出生体重发生率（P = 0.001）高于正常分娩情况。发现头孢曲松/利福平联合用药是治疗感染布鲁氏菌病孕妇的最有效疗法（P = 0.004）。孕期布鲁氏菌病对先天性畸形或死产发生率无影响。早产和低出生体重可视为布鲁氏菌病的妊娠结局。孕期对布鲁氏菌病进行适当的抗菌治疗将降低发病率并预防并发症。
