Max Perutz Labs, University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.
Max Perutz Labs, University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.
Dev Cell. 2020 Dec 7;55(5):517-519. doi: 10.1016/j.devcel.2020.11.005.
The expression of autophagy and lysosomal genes is coordinated by the transcription factor EB (TFEB). In this issue of Developmental Cell, Chen et al. identify an evolutionary conserved mode of TFEB regulation, which entails the inhibition of TFEB phase separation in the nucleus by inositol polyphosphate multikinase.
自噬和溶酶体基因的表达受到转录因子 EB（TFEB）的协调。在本期《发育细胞》中，Chen 等人确定了 TFEB 调节的一种进化保守模式，其中涉及肌醇多磷酸激酶抑制 TFEB 在核内的相分离。
