Department of Neurological Surgery, Doctor's Office Center, Rutgers New Jersey Medical School, 90 Bergen Street, 07101-1709, Newark, NJ, United States.
Department of Neurological Surgery, Doctor's Office Center, Rutgers New Jersey Medical School, 90 Bergen Street, 07101-1709, Newark, NJ, United States.
Clin Neurol Neurosurg. 2021 Jan;200:106374. doi: 10.1016/j.clineuro.2020.106374. Epub 2020 Nov 23.
While CDD directly to the CSF can provide a constant delivery of the dopaminergic drug resulting in a more stable treatment effect without the limitations of traditional oral therapy without peripheral effects, it is still young and longitudinal data is lacking. These experimental therapies show promise and further investigation into their efficacy and safety could extend the frontiers for management of PD.
虽然 CDD 直接向脑脊液输送多巴胺能药物可以提供更稳定的治疗效果，而没有传统口服治疗的局限性和外周效应，但它仍然很年轻，缺乏纵向数据。这些实验性治疗方法显示出前景，进一步研究它们的疗效和安全性可能会扩大 PD 管理的前沿。
