Toledano Manuel, Osorio Raquel, Vallecillo-Rivas Marta, Osorio Estrella, Lynch Christopher D, Aguilera Fátima S, Toledano Raquel, Sauro Salvatore
University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja S/n, Granada, 18071, Spain.
University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja S/n, Granada, 18071, Spain.
J Mech Behav Biomed Mater. 2021 Feb;114:104232. doi: 10.1016/j.jmbbm.2020.104232. Epub 2020 Dec 1.
The objective was to state zinc contribution in the effectiveness of novel zinc-doped dentin cements to achieve dentin remineralization, throughout a literature or narrative exploratory review. Literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. Both zinc-doping silicate and hydroxyapatite-based cements provoked an increase of both bioactivity and intrafibrillar mineralization of dentin. Zinc-doped hydroxyapatite-based cements (oxipatite) also induced an increase in values of dentin nano-hardness, Young's modulus and dentin resistance to deformation. From Raman analyses, it was stated higher intensity of phosphate peaks and crystallinity as markers of dentin calcification, in the presence of zinc. Zinc-based salt formations produced low microleakage and permeability values with hermetically sealed tubules at radicular dentin. Dentin treated with oxipatite attained preferred crystal grain orientation with polycrystalline lattices. Thereby, oxipatite mechanically reinforced dentin structure, by remineralization. Dentin treated with oxipatite produced immature crystallites formations, accounting for high hydroxyapatite solubility, instability and enhanced remineralizing activity.
目的是通过文献或叙述性探索性综述，阐述新型锌掺杂牙本质粘结剂在实现牙本质再矿化有效性方面锌的作用。使用电子数据库进行文献检索，如PubMed、MEDLINE、DIMDI、Embase、Scopus和Web of Science。锌掺杂的硅酸盐和羟基磷灰石基粘结剂均能提高牙本质的生物活性和纤维内矿化程度。锌掺杂的羟基磷灰石基粘结剂（氧磷灰石）还能提高牙本质的纳米硬度、杨氏模量和抗变形能力。拉曼分析表明，在锌存在的情况下，磷酸盐峰强度和结晶度更高，可作为牙本质钙化的标志。锌基盐形成物产生的微渗漏和渗透率值较低，根管牙本质小管被密封。用氧磷灰石处理的牙本质具有多晶晶格的优选晶粒取向。因此，氧磷灰石通过再矿化机械增强了牙本质结构。用氧磷灰石处理的牙本质产生未成熟的微晶结构，这导致羟基磷灰石的高溶解度、不稳定性和增强的再矿化活性。
