Toledano Manuel, Toledano-Osorio Manuel, Hannig Matthias, Carrasco-Carmona Álvaro, Osorio María T, García-Godoy Franklin, Cabello Inmaculada, Osorio Raquel
Faculty of Dentistry, Colegio Máximo de Cartuja s/n, University of Granada, 18017 Granada, Spain.
Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital, Saarland University, Building 73, 66421 Homburg/Saar, Germany.
Polymers (Basel). 2022 Feb 8;14(3):642. doi: 10.3390/polym14030642.
This is a narrative review of the literature assessing the potential effectiveness of doping dentin polymeric adhesives with zinc compounds in order to improve bonding efficacy, remineralization and protection against degradation. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI and Web of Science. Through our search, we found literature demonstrating that Zn-doped dentin adhesives promote protection and remineralization of the resin-dentin interfaces. The increased bioactivity has also facilitated dentinal tubules' occlusion by crystals' precipitation contributing to improved sealing efficacy of restorations. Loading dentin adhesives with zinc gives rise to an increase of both crystallinity of mineral and crosslinking of collagen. The main role of zinc, in dentin adhesives, is to inhibit collagen proteolysis. We concluded that zinc exerts a protective effect through binding at the collagen-sensitive cleavage sites of matrix-metalloproteinases (MMPs), contributing to dentin matrix stabilization. Zinc may not only act as a MMPs inhibitor, but also influence signaling pathways and stimulate metabolic effects in dentin mineralization and remineralization processes. Zn-doped adhesives increase the longevity of dentin bonding through MMPs inhibition. Zn poses a remineralization strategy in demineralized dentin.
这是一篇叙述性文献综述，评估了用锌化合物掺杂牙本质聚合物粘合剂以提高粘结效果、再矿化和抗降解保护的潜在有效性。使用电子数据库进行了文献检索，如PubMed、MEDLINE、DIMDI和科学网。通过检索，我们发现文献表明，锌掺杂牙本质粘合剂可促进树脂-牙本质界面的保护和再矿化。生物活性的提高还通过晶体沉淀促进牙本质小管的封闭，有助于提高修复体的密封效果。用锌加载牙本质粘合剂会导致矿物质结晶度和胶原蛋白交联的增加。锌在牙本质粘合剂中的主要作用是抑制胶原蛋白水解。我们得出结论，锌通过结合基质金属蛋白酶（MMPs）的胶原蛋白敏感裂解位点发挥保护作用，有助于牙本质基质稳定。锌不仅可能作为MMPs抑制剂起作用，还可能影响信号通路并刺激牙本质矿化和再矿化过程中的代谢效应。锌掺杂粘合剂通过抑制MMPs提高牙本质粘结的持久性。锌在脱矿牙本质中构成一种再矿化策略。
