State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.
Int Immunopharmacol. 2021 Jan;90:107194. doi: 10.1016/j.intimp.2020.107194. Epub 2020 Dec 4.
Inflammatory bowel disease (IBD) is a worldwide prototypical complex disease, owing to its multifactorial causes, relapsing and remitting condition and high incidence. Thus, effective therapeutic approaches need to be developed for patients with IBD. Currently, we reported the improving effect of magnesium isoglycyrrhizinate on colitis induced by dextran sulfate sodium (DSS). We found that magnesium isoglycyrrhizinate treatment significantly alleviated DSS-induced acute and chronic colitis by inhibiting the inflammatory response characterized by reduce of the infiltrations of immune cell and the level of pro-inflammatory cytokines. Besides, magnesium isoglycyrrhizinate treatment significantly inhibited the level of ROS and decreased the gut barrier destruction after DSS treatment. Furthermore, the results also showed that administration of magnesium isoglycyrrhizinate significantly reduced the colonic fibrosis. Taken together, these results revealed the potency of magnesium isoglycyrrhizinate on the intestinal inflammation, by which points to the possible use of magnesium isoglycyrrhizinate for IBD therapy in clinical applications.
炎症性肠病（IBD）是一种全球性的典型复杂疾病，由于其多因素的病因、反复发作和高发病率。因此，需要为 IBD 患者开发有效的治疗方法。目前，我们报道了甘草酸镁对葡聚糖硫酸钠（DSS）诱导的结肠炎的改善作用。我们发现，甘草酸镁治疗通过抑制以免疫细胞浸润和促炎细胞因子水平降低为特征的炎症反应，显著缓解 DSS 诱导的急性和慢性结肠炎。此外，甘草酸镁治疗还显著抑制了 DSS 处理后的 ROS 水平并降低了肠道屏障的破坏。此外，结果还表明，甘草酸镁的给药显著减少了结肠纤维化。总之，这些结果揭示了甘草酸镁对肠道炎症的作用，这表明甘草酸镁可能在临床上用于 IBD 的治疗。
