IVPC UMR754 INRA, Univ Lyon, Université Claude Bernard Lyon 1, EPHE, 69007 Lyon, France.
Interspecies Transmission of Arboviruses and Therapeutics Research Unit, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Cells. 2020 Dec 5;9(12):2612. doi: 10.3390/cells9122612.
Alphaviruses, such as the chikungunya virus, are emerging and re-emerging viruses that pose a global public health threat. They are transmitted by blood-feeding arthropods, mainly mosquitoes, to humans and animals. Although alphaviruses cause debilitating diseases in mammalian hosts, it appears that they have no pathological effect on the mosquito vector. Alphavirus/host interactions are increasingly studied at cellular and molecular levels. While it seems clear that apoptosis plays a key role in some human pathologies, the role of cell death in determining the outcome of infections in mosquitoes remains to be fully understood. Here, we review the current knowledge on alphavirus-induced regulated cell death in hosts and vectors and the possible role they play in determining tolerance or resistance of mosquitoes.
甲病毒，如基孔肯雅病毒，是正在出现和重现的病毒，对全球公共卫生构成威胁。它们通过吸血节肢动物，主要是蚊子，传播给人类和动物。虽然甲病毒在哺乳动物宿主中引起使人虚弱的疾病，但它们对蚊子媒介似乎没有病理影响。甲病毒/宿主相互作用在细胞和分子水平上的研究越来越多。虽然细胞凋亡似乎在一些人类病理学中起着关键作用，但细胞死亡在确定蚊子感染结局中的作用仍有待充分理解。在这里，我们综述了宿主和媒介中甲型病毒诱导的细胞程序性死亡的最新知识，以及它们在决定蚊子的耐受性或抗性中可能发挥的作用。
