Chacar Fernanda C, Kogika Márcia M, Zafalon Rafael V A, Brunetto Marcio A
Department of Internal Medicine, Federal Institute of Education, Science and Technology of South of Minas Gerais (IFSULDEMINAS), Muzambinho 37890-000, Brazil.
Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, Brazil.
Metabolites. 2020 Dec 4;10(12):499. doi: 10.3390/metabo10120499.
Some differences regarding Vitamin D metabolism are described in dogs and cats in comparison with humans, which may be explained by an evolutionary drive among these species. Similarly, vitamin D is one of the most important regulators of mineral metabolism in dogs and cats, as well as in humans. Mineral metabolism is intrinsically related to bone metabolism, thus disturbances in vitamin D have been implicated in the development of chronic kidney disease mineral and bone disorders (CKD-MBD) in people, in addition to dogs and cats. Vitamin D deficiency may be associated with Renal Secondary Hyperparathyroidism (RSHPT), which is the most common mineral disorder in later stages of CKD in dogs and cats. Herein, we review the peculiarities of vitamin D metabolism in these species in comparison with humans, and the role of vitamin D disturbances in the development of CKD-MBD among dogs, cats, and people. Comparative studies may offer some evidence to help further research about vitamin D metabolism and bone disorders in CKD.
与人类相比，犬猫体内维生素D代谢存在一些差异，这可能是由这些物种间的进化驱动力所导致的。同样，维生素D在犬猫以及人类体内都是矿物质代谢最重要的调节因子之一。矿物质代谢与骨代谢内在相关，因此，除犬猫外，维生素D紊乱也被认为与人类慢性肾脏病矿物质和骨异常（CKD-MBD）的发生有关。维生素D缺乏可能与肾性继发性甲状旁腺功能亢进（RSHPT）有关，这是犬猫慢性肾脏病晚期最常见的矿物质紊乱。在此，我们综述了这些物种与人类相比维生素D代谢的特点，以及维生素D紊乱在犬、猫和人类CKD-MBD发生中的作用。比较研究可能会为进一步研究CKD中维生素D代谢和骨紊乱提供一些证据。
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