Bounameaux H M, Hellemans H, Verhaege R
Int Angiol. 1986 Jan-Mar;5(1):39-44.
Two local cold provocation tests were carried out in 25 healthy volunteers and in 14 patients with Raynaud's disease, using finger systolic pressure (FSP) and digital blood flow measurements. Mean FSP was significantly lower in Raynaud's patients compared to healthy volunteers at 15 degrees C and 10 degrees C (cuff temperature). Maximal digital flow (at skin temperature of 38 degrees C) was slightly though not significantly lower in Raynaud's patients as compared to normals (27 +/- 3 versus 36 +/- 4 ml/100 ml/min). Upon cooling, statistical significance was reached starting from finger skin temperature of 24 degrees C. Overlap between the two groups was considerable but only 1 out of 13 patients with Raynaud's disease had both tests normal. Ten of the patients participated in a double-blind cross-over trial with naftidrofuryl (200 mg t.i.d.) versus placebo. Significant (p less than 0.05) subjective improvement was noted after 6 weeks with naftidrofuryl but this was not necessarily substantiated by an increased digital flow or pressure in the test situation.
对25名健康志愿者和14名雷诺病患者进行了两项局部冷激发试验，采用手指收缩压（FSP）和指端血流测量。在15摄氏度和10摄氏度（袖带温度）时，雷诺病患者的平均FSP显著低于健康志愿者。与正常人相比，雷诺病患者的最大指端血流（皮肤温度为38摄氏度时）略低，但无显著差异（27±3对36±4毫升/100毫升/分钟）。冷却后，从手指皮肤温度24摄氏度开始达到统计学显著性。两组之间的重叠相当大，但13名雷诺病患者中只有1名两项试验均正常。10名患者参加了一项双盲交叉试验，比较萘呋胺酯（200毫克，每日三次）与安慰剂。服用萘呋胺酯6周后，主观上有显著改善（p<0.05），但在测试情况下，指端血流或压力增加并不一定能证实这一点。
