Buonaguro Franco M, Botti Gerardo, Ascierto Paolo Antonio, Pignata Sandro, Ionna Franco, Delrio Paolo, Petrillo Antonella, Cavalcanti Ernesta, Di Bonito Maurizio, Perdonà Sisto, De Laurentiis Michelino, Fiore Francesco, Palaia Raffaele, Izzo Francesco, D'Auria Stefania, Rossi Virginia, Menegozzo Simona, Piccirillo Mauro, Celentano Egidio, Cuomo Arturo, Normanno Nicola, Tornesello Maria Lina, Saviano Rocco, Barberio Daniela, Buonaguro Luigi, Giannoni Giovanni, Muto Paolo, Miscio Leonardo, Bianchi Attilio A M
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.
Infect Agent Cancer. 2020 Nov 23;15(1):69. doi: 10.1186/s13027-020-00330-7.
COVID-19 pandemic following the outbreak in China and Western Europe, where it finally lost the momentum, is now devastating North and South America. It has not been identified the reason and the molecular mechanisms of the two different patterns of the pulmonary host responses to the virus from a minimal disease in young subjects to a severe distress syndrome (ARDS) in older subjects, particularly those with previous chronic diseases (including diabetes) and cancer. The Management of the Istituto Nazionale Tumori - IRCCS "Fondazione Pascale" in Naples (INT-Pascale), along with all Health professionals decided not to interrupt the treatment of those hospitalized and to continue, even if after a careful triage in order not to allow SARS-CoV-2 positive subjects to access, to take care of cancer patients with serious conditions. Although very few (n = 3) patients developed a symptomatic COVID-19 and required the transfer to a COVID-19 area of the Institute, no patients died during the hospitalization and completed their oncology treatment. Besides monitoring of the patients, all employees of the Institute (physicians, nurses, researchers, lawyers, accountants, gatekeepers, guardians, janitors) have been tested for a possible exposure. Personnel identified as positive, has been promptly subjected to home quarantine and subdued to health surveillance. One severe case of respiratory distress has been reported in a positive employees and one death of a family member. Further steps to home monitoring of COVID-19 clinical course have been taken with the development of remote Wi-Fi connected digital devices for the detection of early signs of respiratory distress, including heart rate and oxygen saturation.In conclusion cancer care has been performed and continued safely also during COVID-19 pandemic and further remote home strategies are in progress to ensure the appropriate monitoring of cancer patients.
在中国和西欧爆发并最终失去势头的新冠疫情，如今正在肆虐南北美洲。尚未明确从年轻受试者的轻微疾病到老年受试者（尤其是那些患有既往慢性病（包括糖尿病）和癌症的患者）出现严重呼吸窘迫综合征（ARDS）的两种不同肺部宿主对病毒反应模式的原因及分子机制。那不勒斯的国家肿瘤研究所 - IRCCS“帕斯卡尔基金会”（INT - 帕斯卡尔）的管理层与所有医护人员决定不中断对住院患者的治疗，并继续（即使经过仔细分诊以防止新冠病毒阳性患者进入）照顾病情严重的癌症患者。尽管只有极少数（n = 3）患者出现有症状的新冠病毒感染并需要转至该研究所的新冠专区，但住院期间没有患者死亡，且他们完成了肿瘤治疗。除了对患者进行监测外，该研究所的所有员工（医生、护士、研究人员、律师、会计、门卫、监护人、勤杂工）都接受了可能暴露情况的检测。被确定为阳性的人员已被迅速进行居家隔离并接受健康监测。一名阳性员工报告出现了严重呼吸窘迫病例，一名家庭成员死亡。随着用于检测包括心率和血氧饱和度在内的呼吸窘迫早期迹象的远程Wi - Fi连接数字设备的开发，已采取了进一步的居家监测新冠临床病程的措施。总之，在新冠疫情期间也安全地开展并持续了癌症护理工作，并且正在推进进一步的远程居家策略以确保对癌症患者进行适当监测。
