Jenkins Zoe M, Chait Lior M, Cistullo Leonardo, Castle David J
Mental Health Service, St. Vincent's Hospital, Melbourne, Australia.
Department of Psychiatry, University of Melbourne, Melbourne, Australia.
J Eat Disord. 2020 Nov 4;8(1):56. doi: 10.1186/s40337-020-00337-w.
Epidemiological studies suggest that the incidence of anorexia nervosa (AN) is increasing in younger populations, with some evidence that clinical differences occur according to age of onset (AOO), which may impact prognostic outcomes. The current study sought to compare eating disorder (ED) symptomatology, psychological distress and psychosocial function between early onset (EO), typical onset (TO) and later onset (LO) AN in a large sample of treatment-seeking patients with a diagnosis of AN.
Participants included 249 individuals with a diagnosis of AN who were assessed at an outpatient ED service. The sample was divided into three groups based on AOO; those with an AOO ≤14 years (N = 58) were termed 'EO-AN', those with an AOO between 15 and 18 years (N = 113) were termed 'TO-AN' and those with an AOO of > 18 years (N = 78) were termed 'LO-AN'. Comparisons were made between AOO groups on assessments of ED symptomatology, psychological distress and psychosocial function.
EO-AN patients reported a significantly longer illness duration than both TO-AN and LO-AN groups. After controlling for effect of illness duration, the EO-AN group demonstrated significantly higher ED symptomatology and dysmorphic concern compared to the LO-AN group. The EO-AN group demonstrated significantly decreased cognitive flexibility compared to both the TO-AN and LO-AN groups.
These findings suggest that clinical differences do occur according to AOO in AN whereby EO-AN may represent a more severe form of illness that is not attributable to increased illness duration. Treatment strategies which specifically address patients with EO-AN may improve long term health outcomes and recovery.
流行病学研究表明,神经性厌食症(AN)在年轻人群中的发病率正在上升,有证据表明,根据发病年龄(AOO)会出现临床差异,这可能会影响预后结果。本研究旨在比较大量寻求治疗的AN诊断患者中早发型(EO)、典型发型(TO)和晚发型(LO)AN之间的饮食失调(ED)症状、心理困扰和心理社会功能。
参与者包括249名诊断为AN的个体,他们在门诊ED服务中接受了评估。样本根据AOO分为三组;AOO≤14岁的患者(N = 58)被称为“早发型AN(EO-AN)”,AOO在15至18岁之间的患者(N = 113)被称为“典型发型AN(TO-AN)”,AOO>18岁的患者(N = 78)被称为“晚发型AN(LO-AN)”。对AOO组在ED症状、心理困扰和心理社会功能评估方面进行了比较。
早发型AN患者报告的病程明显长于典型发型AN组和晚发型AN组。在控制病程影响后,早发型AN组与晚发型AN组相比,表现出明显更高的ED症状和畸形关注。与典型发型AN组和晚发型AN组相比,早发型AN组的认知灵活性明显降低。
这些发现表明,在AN中确实会根据AOO出现临床差异,即早发型AN可能代表一种更严重的疾病形式,这并非归因于病程延长。专门针对早发型AN患者的治疗策略可能会改善长期健康结果和康复情况。