Lee Kyuwan, Sami Nathalie, Tripathy Debu, Demark-Wahnefried Wendy, Norris Mary K, Courneya Kerry S, Dieli-Conwright Christina M
Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Cardiooncology. 2020 Nov 24;6(1):27. doi: 10.1186/s40959-020-00084-6.
Breast cancer survivors have double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score (RRS) is a validated algorithm for the assessment of cardiovascular disease risk. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on RRS in overweight or obese breast cancer survivors.
One hundred overweight or obese (BMI > 25 kg/m) breast cancer survivors were randomized to exercise or usual care. The exercise group underwent aerobic and resistance exercise sessions for 16 weeks. RRS was calculated using a validated equation. Group differences in mean change for RRS were evaluated using repeated-measures analyses of variance. Post-intervention, RRS was significantly reduced (7.9 ± 0.9% to 1.0 ± 0.5%; p < 0.001) in the exercise group compared to a significant increase (9.0 ± 0.8% to 11.6 ± 1.2%; p = 0.002%) in the usual care group (p < 0.01). RRS was significantly reduced in exercise vs usual care (between group difference, - 10.6; 95% CI, - 16.3 to - 7.4; p < 0.001).
A 16-week aerobic and resistance exercise intervention is an effective approach to reduce the risk of cardiovascular disease in breast cancer survivors. Exercise during cancer survivorship should be considered to reduce the risk for cardiovascular disease risk in overweight women breast cancer survivors.
ClinicalTrials.gov: NCT01140282 . Registered 9 June 2010.
乳腺癌幸存者死于心血管疾病的风险是无癌症病史的同龄女性的两倍。雷诺兹风险评分（RRS）是一种经过验证的评估心血管疾病风险的算法。这项二次分析旨在研究为期16周的有氧和抗阻运动干预对超重或肥胖乳腺癌幸存者RRS的影响。
100名超重或肥胖（BMI>25kg/m）的乳腺癌幸存者被随机分为运动组或常规护理组。运动组进行了为期16周的有氧和抗阻运动训练。使用经过验证的公式计算RRS。采用重复测量方差分析评估RRS平均变化的组间差异。干预后，运动组的RRS显著降低（从7.9±0.9%降至1.0±0.5%；p<0.001），而常规护理组则显著升高（从9.0±0.8%升至11.6±1.2%；p=0.002%）（p<0.01）。运动组与常规护理组相比，RRS显著降低（组间差异为-10.6；95%CI，-16.3至-7.4；p<0.001）。
为期16周的有氧和抗阻运动干预是降低乳腺癌幸存者心血管疾病风险的有效方法。应考虑在癌症康复期间进行运动，以降低超重乳腺癌幸存者患心血管疾病的风险。
ClinicalTrials.gov：NCT01140282。于2010年6月9日注册。
