Onuh John O, Aliani Michel
Center for Molecular and Translational Medicine, Georgia State University, 100 Piedmont Ave SE, Atlanta, GA, 30303, USA.
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
Clin Hypertens. 2020 Nov 15;26(1):23. doi: 10.1186/s40885-020-00157-9.
Hypertension is a chronic health condition in which blood pressure is usually elevated beyond normal levels. It can progress with serious complications if left undetected and untreated. Incidence of hypertension is on the increase worldwide with debilitating consequences on the health systems of many countries. It is a multifactorial disorder that requires a multi-pronged approach to address it. One such approach is the use of metabolomics or metabolite profiling to understand its underlying cause and possibly control it. Changes in metabolites profiles have been used to accurately predict so many disease conditions in addition to identifying possible biomarkers and pathways associated in their pathogenicity. This will enable their early detection, diagnosis and treatment as well as likely complications that may arise and also assist in development of biomarkers for clinical uses. The objective of this review therefore is to present some of the current knowledge on the application of metabolomics profiling in hypertension and blood pressure control.
高血压是一种慢性健康状况，其血压通常会升高到正常水平以上。如果未被发现和治疗，它可能会发展并引发严重并发症。全球高血压的发病率正在上升，给许多国家的卫生系统带来了严重后果。它是一种多因素疾病，需要采取多管齐下的方法来解决。其中一种方法是使用代谢组学或代谢物谱分析来了解其潜在原因并可能对其进行控制。除了识别与其致病性相关的可能生物标志物和途径外，代谢物谱的变化还被用于准确预测许多疾病状况。这将有助于早期发现、诊断和治疗，以及可能出现的并发症，并有助于开发临床应用的生物标志物。因此，本综述的目的是介绍一些关于代谢组学谱分析在高血压和血压控制中的应用的当前知识。
