Hageleit U, Will C H, Seidel D
Department of Radiology, St. Agnes Hospital, Bocholt, West Germany.
Neurosurg Rev. 1987;10(2):137-40. doi: 10.1007/BF01741451.
An automated method of measuring cerebral atrophy is introduced. Using this method we studied patients with multiple sclerosis and a control group showing premature cerebral atrophy in multiple sclerosis (P = 1,32 x 10(-8) for male and P = 3,6 x 10(-14) for female). There was only a weak correlation between cerebral atrophy and psychological deficits. Multivariate analysis did not show any significant correlation between cerebral atrophy, duration of disease, clinical manifestations and progression of disease. We conclude that our method to measure cerebral atrophy is more accurate and less time-consuming than the use of linear indices. It might be appropriate for further investigations in evaluating atrophic processes in cerebro-vascular, degenerative and exogen-toxic disease of brain.
介绍了一种测量脑萎缩的自动化方法。使用该方法，我们研究了多发性硬化症患者以及一个对照组，该对照组显示出多发性硬化症患者存在过早脑萎缩（男性P = 1.32×10⁻⁸，女性P = 3.6×10⁻¹⁴）。脑萎缩与心理缺陷之间仅存在微弱的相关性。多变量分析未显示脑萎缩、病程、临床表现和疾病进展之间存在任何显著相关性。我们得出结论，我们测量脑萎缩的方法比使用线性指标更准确且耗时更少。它可能适用于进一步研究评估脑血管、退行性和外源性脑中毒疾病中的萎缩过程。
