Cancer Research Initiative, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa
School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa.
BMJ Open. 2020 Dec 7;10(12):e042788. doi: 10.1136/bmjopen-2020-042788.
Breast and cervical cancers pose a major public health burden globally, with disproportionately high incidence, morbidity and mortality in low- and middle-income countries (LMICs). The majority of women diagnosed with cancer in LMICs present with late-stage disease, the treatment of which is often costlier and less effective. While interventions to improve the timely diagnosis of these cancers are increasingly being implemented in LMICs, there is uncertainty about their role and effectiveness. The aim of this review is to systematically synthesise available evidence on the nature and effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in LMICs.
A comprehensive search of published and relevant grey literature will be conducted. The following electronic databases will be searched: MEDLINE (via PubMed), Cochrane Library, Scopus, CINAHL, Web of Science and the International Clinical Trials Registry Platform (ICTRP). Evidence will be synthesised in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). Two reviewers will independently screen the search outputs, select studies using predefined inclusion criteria and assess each included study for risk of bias. If sufficient data are available and studies are comparable in terms of interventions and outcomes, a meta-analysis will be conducted. Where studies are not comparable and a meta-analysis is not appropriate, a narrative synthesis of findings will be reported.
As this will be a systematic review of publicly available data, with no primary data collection, it will not require ethical approval. Findings will be disseminated widely through a peer-reviewed publication and forums such as conferences, workshops and community engagement sessions. This review will provide a user-friendly evidence summary for informing further efforts at developing and implementing interventions for addressing delays in breast and cervical cancer diagnosis in LMICs.
CRD42020177232.
乳腺癌和宫颈癌在全球范围内构成了重大的公共卫生负担，在中低收入国家（LMICs）发病率、发病率和死亡率过高。在 LMICs 中诊断出的大多数癌症患者都处于晚期，而晚期癌症的治疗通常更昂贵且效果更差。虽然越来越多的干预措施被用于改善这些癌症的及时诊断，但对于这些干预措施的作用和效果仍然存在不确定性。本综述旨在系统地综合评估改善 LMICs 中乳腺癌和宫颈癌及时诊断的干预措施的性质和效果。
将对已发表和相关灰色文献进行全面搜索。将在以下电子数据库中进行搜索：MEDLINE（通过 PubMed）、Cochrane 图书馆、Scopus、CINAHL、Web of Science 和国际临床试验注册平台（ICTRP）。将根据系统评价和荟萃分析的首选报告项目（PRISMA）对证据进行综合。两名审查员将独立筛选搜索结果，使用预定义的纳入标准选择研究，并评估每一项纳入研究的偏倚风险。如果有足够的数据并且研究在干预措施和结果方面具有可比性，则将进行荟萃分析。如果研究不可比且不适合进行荟萃分析，则将报告结果的叙述性综合。
由于这将是对公开数据的系统综述，没有原始数据收集，因此不需要伦理批准。研究结果将通过同行评审出版物以及会议、研讨会和社区参与会议等论坛广泛传播。本综述将提供一个易于使用的证据摘要，为进一步开发和实施干预措施提供信息，以解决 LMICs 中乳腺癌和宫颈癌诊断延迟的问题。
CRD42020177232（PROSPERO 注册号）。
