Pongponratn E, Riganti M, Bunnag D, Harinasuta T
Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Thailand.
Southeast Asian J Trop Med Public Health. 1987 Dec;18(4):491-501.
An ultrastructural study was undertaken of the spleen of 13 year-old-boy who died of falciparum malaria. The spleen revealed the following: both parasitized and non-parasitized erythrocytes are phagocytosed in large numbers by macrophages, littoral and reticular cells. Blood congestion and trapping of parasitized erythrocytes are commonly seen in splenic sinusoids and cords. Erythrocytes forming rosette structure around immuno-presenting cells is observed. The results of this study provide evidence that the mechanisms underlying splenic host defence in malaria include both immunological and non-immunological interaction with erythrocytes. Splenic trapping of parasitized erythrocytes is an important defence mechanism and the phagocytosis of erythrocytes probably accounts for anaemia.
对一名死于恶性疟的13岁男孩的脾脏进行了超微结构研究。脾脏呈现出以下情况：巨噬细胞、边缘细胞和网状细胞大量吞噬被寄生和未被寄生的红细胞。脾血窦和脾索中常见血液淤滞以及被寄生红细胞的滞留。观察到红细胞围绕免疫呈递细胞形成玫瑰花结结构。本研究结果表明，疟疾中脾脏宿主防御的潜在机制包括与红细胞的免疫和非免疫相互作用。脾脏对被寄生红细胞的滞留是一种重要的防御机制，而红细胞的吞噬作用可能是贫血的原因。
