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一名患有脑穿通畸形囊肿和蛛网膜囊肿的无症状女性怀孕

Pregnancy in an Asymptomatic Woman with Porencephalic and Arachnoid Cysts.

作者信息

Pepe Franco, Marchese Gianmarco, Pepe Gabriele Giuseppe, Zambrotta Elisabetta, Insalaco Giulio, Garraffo Claudia, La Rosa Valeria

机构信息

Ospedale San Marco, Ostetricia e Ginecologia con Pronto Soccorso, Catania, Italy.

Dipartimento di Neurochirurgia, UOV Careggi, Firenze, Italy.

出版信息

Case Rep Obstet Gynecol. 2020 Nov 18;2020:8885114. doi: 10.1155/2020/8885114. eCollection 2020.

DOI:10.1155/2020/8885114
PMID:33294241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7691000/
Abstract

A 25-year-old woman presented to the obstetric clinic in her first pregnancy. The patient was accompanied by her mother who reported an episode of intracerebral hemorrhage after birth and also remembered access to the emergency department after generalized tonic-clonic seizure as an infant. She was not able to describe the therapy for seizure preventions and even when and why it was suspended, but she affirmed that no residual neurological consequences were detected in the following years. Actually, the pregnant woman was in good health without neurological symptoms nor assumed any therapy. A neurologist reviewed the patient's CT scan in which arachnoid cyst and porencephalic cyst were evident, and he assessed that no abnormalities were found in motor, sensory, and mental state examination. EEG did not show any epileptiform or seizure-like activity. No antiepileptic drug was prescribed due to the absence of symptoms since many years. The patient had no neurological symptoms during pregnancy or obstetric complications and delivered at term a healthy baby through a caesarean section. She breastfed, and after two years, the patient and the baby are healthy. The association of porencephalic and arachnoid cyst in pregnancy is an extremely rare neurological condition that needs a multidisciplinary counseling in pregnancy, but an uneventful course is possible.

摘要

一名25岁的女性首次怀孕时前往产科诊所就诊。患者由其母亲陪同,其母亲报告称患者出生后曾发生脑出血,还记得患者婴儿期出现全身强直阵挛性癫痫发作后曾前往急诊科。她无法描述预防癫痫发作的治疗方法,甚至记不起治疗何时以及为何中止,但她确认在接下来的几年里未发现任何神经后遗症。实际上,该孕妇身体健康,没有神经症状,也未接受任何治疗。一位神经科医生查看了患者的CT扫描,其中蛛网膜囊肿和脑穿通畸形囊肿明显可见,他评估在运动、感觉和精神状态检查中未发现异常。脑电图未显示任何癫痫样或癫痫发作样活动。由于多年来没有症状,未开抗癫痫药物。患者在怀孕期间没有神经症状或产科并发症,足月通过剖宫产分娩了一个健康的婴儿。她进行母乳喂养,两年后,患者和婴儿都很健康。怀孕期间脑穿通畸形囊肿和蛛网膜囊肿并存是一种极其罕见的神经疾病,孕期需要多学科会诊,但也可能顺利度过孕期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/7691000/4cfb4e49f005/CRIOG2020-8885114.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/7691000/377b49c7e558/CRIOG2020-8885114.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/7691000/4cebb381fb95/CRIOG2020-8885114.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/7691000/4cfb4e49f005/CRIOG2020-8885114.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/7691000/377b49c7e558/CRIOG2020-8885114.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/7691000/4cebb381fb95/CRIOG2020-8885114.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62d8/7691000/4cfb4e49f005/CRIOG2020-8885114.003.jpg

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本文引用的文献

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Porencephalic cyst: a rare cause of new-onset seizure in an adult.脑穿通畸形囊肿:成人新发癫痫的罕见病因。
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Phenotypic spectrum of COL4A1 mutations: porencephaly to schizencephaly.COL4A1 基因突变的表型谱:脑裂畸形到脑裂畸形。
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