长链非编码RNA FOXD1-AS1通过维持FOXD1表达促进鼻咽癌的进展和糖酵解。
Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression.
作者信息
Wang Zhanwang, Cheng Yaxin, Zhu Yuxing, Hu Xueying, Jin Yi, Gong Lian, Xiao Mengqing, Xiang Liang, Zeng Qinghai, Liu Jianye, Chen Xingyu, Zhang Yeyu, Liu Xiaoming, Deng Liping, He Dong, Cao Ke
机构信息
Department of Oncology, Third Xiangya Hospital of Central South University Changsha 410013, China.
Department of Dermatology, Third Xiangya Hospital of Central South University Changsha 410013, China.
出版信息
Am J Cancer Res. 2020 Nov 1;10(11):3686-3704. eCollection 2020.
Abstract
Long non-coding RNAs (lncRNAs) play a vital role in the progression of several cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism of lncRNA involvement in the progression of NPC remains to be elucidated. Hence, we conducted in vivo and in vitro experiments to determine the molecular mechanism of FOXD1-AS1. We found that FOXD1-AS1 was over-expressed in NPC cells and tissues, and was significantly associated with poor survival rate in patients with NPC. We also found that FOXD1-AS1 promotes cellular proliferation, migration, invasion, and glycolysis, and inhibits apoptosis by upregulating the expression of FOXD1. Furthermore, FOXD1 could transcriptionally up-regulate the expression of key glycolytic genes to promote the glycolysis levels of NPC. The identified FOXD1-AS1 may serve as a potential prognostic biomarker and therapeutic target for patients with NPC.
摘要
长链非编码RNA（lncRNAs）在包括鼻咽癌（NPC）在内的多种癌症进展中起着至关重要的作用。然而，lncRNA参与NPC进展的机制仍有待阐明。因此，我们进行了体内和体外实验以确定FOXD1-AS1的分子机制。我们发现FOXD1-AS1在NPC细胞和组织中过表达，并且与NPC患者的低生存率显著相关。我们还发现FOXD1-AS1通过上调FOXD1的表达促进细胞增殖、迁移、侵袭和糖酵解，并抑制细胞凋亡。此外，FOXD1可以转录上调关键糖酵解基因的表达以促进NPC的糖酵解水平。所鉴定的FOXD1-AS1可能作为NPC患者潜在的预后生物标志物和治疗靶点。
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