有毒和解毒内毒素对大鼠天然抗DNA抗体水平的年龄依赖性影响。

Age dependent effect of toxic and detoxified endotoxins on the natural anti-DNA antibody level in rats.

作者信息

Elekes E, Merétey K, Bertók L

机构信息

Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.

出版信息

Acta Microbiol Hung. 1987;34(3-4):225-32.

Abstract

Toxic endotoxin (LPS) and its irradiated detoxified form (RD-LPS) induced only small changes in the DNA level in the sera of 4, 12 and 18 months old rats. Changes in the anti-DNA titres were age-dependent. In 4 months old rats one or two injections of the LPS preparations failed to increase the circulating anti-DNA level. In 12 and 18 months old rats both toxic and detoxified LPS preparations raised the anti-DNA titres. The second LPS injection evoked a smaller response in 18 months old rats than the first one.

摘要

有毒内毒素（LPS）及其经辐照解毒的形式（RD-LPS）在4个月、12个月和18个月龄大鼠血清中的DNA水平仅引起微小变化。抗DNA滴度的变化与年龄有关。在4个月龄的大鼠中，注射一或两次LPS制剂未能提高循环抗DNA水平。在12个月和18个月龄的大鼠中，有毒和解毒的LPS制剂均提高了抗DNA滴度。第二次注射LPS在18个月龄大鼠中引起的反应比第一次小。

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