来自感染牛白血病病毒的奶牛乳汁细胞外囊泡的蛋白质组学分析数据。
Data on proteomic analysis of milk extracellular vesicles from bovine leukemia virus-infected cattle.
作者信息
Rahman Md Matiur, Badr Yassien, Kamatari Yuji O, Kitamura Yuko, Shimizu Kaori, Okada Ayaka, Inoshima Yasuo
机构信息
The United Graduate School of Veterinary Sciences, Gifu University, Japan.
Laboratory of Food and Environmental Hygiene, Cooperative Department of Veterinary Medicine, Gifu University, Japan.
出版信息
Data Brief. 2020 Nov 10;33:106510. doi: 10.1016/j.dib.2020.106510. eCollection 2020 Dec.
Milk extracellular vesicles (EVs) are nanoparticles that contain proteins, mRNAs, microRNAs, DNAs, and lipids that involved in several biological functions. Milk EVs provide proteins that could represent relevant novel biomarkers for monitoring of different diseases such as breast cancer and mastitis in humans and animals, respectively. Bovine leukemia virus (BLV) is an oncogenic virus that causes progressive B-cell lymphosarcoma in cattle. Here, we aimed to identify proteins in milk EVs from BLV-infected cattle compared with those from uninfcetd cattle. Proteomic analysis was performed by using a comprehensive nano liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) approach. Identified proteins were analyzed by using a proteomic software, Scaffold-Data Independent Acquisition (Scaffold-DIA).
乳汁细胞外囊泡（EVs）是包含蛋白质、信使核糖核酸（mRNAs）、微小核糖核酸（microRNAs）、脱氧核糖核酸（DNAs）和脂质的纳米颗粒，这些物质参与多种生物学功能。乳汁细胞外囊泡提供的蛋白质可能分别代表用于监测人类乳腺癌和动物乳腺炎等不同疾病的相关新型生物标志物。牛白血病病毒（BLV）是一种致癌病毒，可导致牛发生进行性B细胞淋巴瘤。在此，我们旨在鉴定感染BLV的奶牛乳汁细胞外囊泡中的蛋白质，并与未感染奶牛的进行比较。通过使用全面的纳米液相色谱-串联质谱（nanoLC-MS/MS）方法进行蛋白质组学分析。使用蛋白质组学软件Scaffold-数据独立采集（Scaffold-DIA）对鉴定出的蛋白质进行分析。
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