Rodrigues Pedro, Cunha Virgínia, Oliva-Teles Luís, Ferreira Marta, Guimarães Laura
CIIMAR/CIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, s/n 4450-208 Matosinhos, Portugal.
Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal.
Data Brief. 2020 Nov 10;33:106515. doi: 10.1016/j.dib.2020.106515. eCollection 2020 Dec.
The data presented herein relates to the article entitled "Norfluoxetine and venlafaxine in zebrafish larvae: single and combined toxicity of two pharmaceutical products relevant for risk assessment" [1]. Recent studies have shown the occurrence of active metabolites of human and veterinary pharmaceuticals in surface and wastewaters. Besides their biological activity, some are predicted to interact with the same molecular targets of their parental compounds, thus showing the potential to elicit detrimental effects on animals. Despite this, limited investigation on their effects on aquatic animals has been done. Genomic material resulting from zebrafish () larvae exposed to the psychoactive compounds norfluoxetine (main fluoxetine metabolite), venlafaxine, or their mixture was collected for gene expression analysis of a determined pool of genes potentially involved in their mode-of-action and metabolism. Molecular parameters are a cost-effective and reliable way to understand modes-of-action and the potential risk of micropollutants, such as pharmaceutical products, in non-target organisms. Moreover, gene expression patterns can provide crucial complementary information to improve risk assessment, and monitoring of affected systems. The data reported in this article was used to depict the effects of single or combined exposure to norfluoxetine and venlafaxine and identify biomarkers of exposure to these compounds of interest to diagnose exposure and routine monitoring.
本文所呈现的数据与题为《斑马鱼幼体中的去甲氟西汀和文拉法辛：两种与风险评估相关的药品的单一及联合毒性》[1]的文章相关。近期研究表明，人类和兽用药品的活性代谢物在地表水和废水中出现。除了它们的生物活性外，一些代谢物预计会与它们母体化合物的相同分子靶点相互作用，从而显示出对动物产生有害影响的可能性。尽管如此，对它们对水生动物影响的研究仍然有限。收集暴露于精神活性化合物去甲氟西汀（主要的氟西汀代谢物）、文拉法辛或其混合物的斑马鱼幼体产生的基因组材料，用于对一组确定的可能涉及其作用方式和代谢的基因进行基因表达分析。分子参数是了解非靶标生物中诸如药品等微污染物的作用方式和潜在风险的一种经济高效且可靠的方法。此外，基因表达模式可以提供关键的补充信息，以改进风险评估以及对受影响系统的监测。本文报道的数据用于描述去甲氟西汀和文拉法辛单一或联合暴露的影响，并识别对这些感兴趣化合物的暴露生物标志物，以诊断暴露情况和进行常规监测。
