Department of Public Health Sciences, Clemson University, Clemson, SC, USA.
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Paediatr Perinat Epidemiol. 2021 May;35(3):350-358. doi: 10.1111/ppe.12736. Epub 2020 Dec 8.
Whether maternal vitamin D affects offspring socioemotional development in early childhood has been underexplored.
This study examined associations between maternal vitamin D during in the 3rd trimester and offspring socioemotional development between 30 and 59 months.
Data from 87 maternal-offspring pairs enrolled in the National Children's Study were used. Total plasma maternal vitamin D (25-hydroxyergocalciferol + 25-hydroxycholecalciferol) was measured between 28 and 35 gestational weeks and categorised as quartiles (Q). Multivariable regression models, adjusting for maternal race/ethnicity, education, and prepregnancy body mass index (BMI [kg/m ]), were used to estimate the association between vitamin D and offspring scores on the Brief Infant-Toddler Social and Emotional Assessment (BITSEA).
The mean (standard deviation) vitamin D concentration was 86.5 (27.8) nmol/L. The median (range) BITSEA problem score was 6.0 (0.0-30.0), and competence score was 19.0 (7.0-22.0). Maternal vitamin D was inversely related to offspring problem scores. Compared to offspring of women with 25(OH)D in Q1, offspring problem scores were -4.80 (95% confidence interval [CI] -8.29, -1.33) units lower for Q2 vs Q1, -5.64 (95% CI -9.60, -1.68) units lower for Q3 vs Q1, and -4.70 (95% CI -8.59, -0.82) units lower for Q4 vs Q1. Vitamin D was not associated with offspring competence score.
Higher maternal vitamin D was associated with lower offspring behaviour problems and not associated with socioemotional competence. These data indicate the association of maternal vitamin D and offspring development may be dependent on the specific developmental component being investigated.
母体维生素 D 是否会影响幼儿期的后代社会情感发展尚未得到充分探索。
本研究旨在探讨妊娠晚期母体维生素 D 与 30 至 59 个月时后代社会情感发育之间的关系。
使用了来自国家儿童研究中 87 对母婴的资料。在 28 至 35 孕周期间测量了母体总血浆维生素 D（25-羟胆钙化醇+25-羟维生素 D），并将其分为四分位数（Q）。使用多变量回归模型，调整了母体种族/民族、教育程度和孕前体重指数（BMI[kg/m2]），来估计维生素 D 与婴儿-幼儿社会情感评估（BITSEA）中后代得分之间的关系。
维生素 D 浓度的平均值（标准差）为 86.5（27.8）nmol/L。BITSEA 问题得分的中位数（范围）为 6.0（0.0-30.0），能力得分中位数为 19.0（7.0-22.0）。母体维生素 D 与后代问题得分呈负相关。与 Q1 中 25（OH）D 水平较低的女性的后代相比，Q2 与 Q1 相比，后代问题得分降低了-4.80（95%置信区间[CI]：-8.29，-1.33）单位，Q3 与 Q1 相比降低了-5.64（95% CI：-9.60，-1.68）单位，Q4 与 Q1 相比降低了-4.70（95% CI：-8.59，-0.82）单位。维生素 D 与后代的能力得分无关。
母体维生素 D 水平较高与后代行为问题较少有关，而与社会情感能力无关。这些数据表明，母体维生素 D 与后代发育之间的关联可能取决于正在研究的特定发育成分。
