Daraki V, Roumeliotaki T, Chalkiadaki G, Katrinaki M, Karachaliou M, Leventakou V, Vafeiadi M, Sarri K, Vassilaki M, Papavasiliou S, Kogevinas M, Chatzi L
Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.
Department of Endocrinology Diabetes and Metabolic Diseases, University Hospital of Crete, Heraklion, Greece.
Pediatr Obes. 2018 Aug;13(8):467-475. doi: 10.1111/ijpo.12267. Epub 2018 Jan 28.
Vitamin D may modulate adipogenesis. However, limited studies have investigated the effect of maternal vitamin D during pregnancy on offspring adiposity or cardiometabolic parameters with inconclusive results.
The objective of this study is to examine the association of maternal 25(OH)-vitamin D [25(OH)D] status with offspring obesity and cardiometabolic characteristics in 532 mother-child pairs from the prospective pregnancy cohort Rhea in Crete, Greece.
Maternal 25(OH)D concentrations were measured at the first prenatal visit (mean: 14 weeks, SD: 4). Child outcomes included body mass index standard deviation score, waist circumference, skin-fold thickness, blood pressure and serum lipids at ages 4 and 6 years. Body fat percentage was also measured at 6 years. Body mass index growth trajectories from birth to 6 years were estimated by mixed effects models with fractional polynomials of age. Adjusted associations were obtained via multivariable linear regression analyses.
About two-thirds of participating mothers had 25(OH)D concentrations <50 nmol L . Offspring of women in the low 25(OH)D tertile (<37.7 nmol L ) had higher body mass index standard deviation score (β 0.20, 95% CI: 0.03, 0.37), and waist circumference (β 0.87 95% CI: 0.12, 1.63) at preschool age, compared with the offspring of women with higher 25(OH)D measurements (≥37.7 nmol L ), on covariate-adjusted analyses. The observed relationships persisted at age 6 years. We found no association between maternal 25(OH)D concentrations and offspring blood pressure or serum lipids at both time points.
Exposure to very low 25(OH)D concentrations in utero may increase childhood adiposity indices. Given that vitamin D is a modifiable risk factor, our findings may have important public health implications.
维生素D可能会调节脂肪生成。然而，仅有有限的研究探讨了孕期母亲维生素D水平对后代肥胖或心脏代谢参数的影响，且结果尚无定论。
本研究旨在调查希腊克里特岛前瞻性妊娠队列Rhea中532对母婴，母亲25-羟基维生素D[25(OH)D]水平与后代肥胖及心脏代谢特征之间的关联。
在首次产前检查时（平均孕周14周，标准差4周）测量母亲的25(OH)D浓度。儿童的观察指标包括4岁和6岁时的体重指数标准差评分、腰围、皮褶厚度、血压和血脂。6岁时还测量了体脂百分比。采用含年龄分数多项式的混合效应模型估计出生至6岁的体重指数增长轨迹。通过多变量线性回归分析获得校正后的关联。
约三分之二参与研究的母亲25(OH)D浓度<50 nmol/L。在协变量校正分析中，与25(OH)D水平较高（≥37.7 nmol/L）的母亲的后代相比，处于25(OH)D三分位数最低组（<37.7 nmol/L）的母亲的后代在学龄前有更高的体重指数标准差评分（β=0.20，95%置信区间：0.03，0.37）和腰围（β=0.87，95%置信区间：0.12，1.63）。在6岁时，观察到的这种关系依然存在。我们发现，在两个时间点，母亲的25(OH)D浓度与后代血压或血脂之间均无关联。
子宫内暴露于极低的25(OH)D浓度可能会增加儿童肥胖指数。鉴于维生素D是一个可改变的风险因素，我们的研究结果可能具有重要的公共卫生意义。
