111374Harran University, Faculty of Medicine, Department of Pediatrics, Sanliurfa, Turkey.
111374Harran University, Faculty of Medicine, Department of Pediatric Neurology, Sanliurfa, Turkey.
Hum Exp Toxicol. 2021 Jun;40(6):952-959. doi: 10.1177/0960327120979349. Epub 2020 Dec 9.
Copeptin is a hypothalamic stress hormone that is synthesized in the hypothalamus together with Arginine-vasopressin and circulated from the neurohypophysis in equimolar amounts and can indicate the individual stress level. The aim of this study was to investigate the plasma copeptin level for childhood migraine headache. In this study, total oxidant status (TOS); total antioxidant status (TAS); oxidative stress index (OSI); and copeptin were measured in the plasma samples of 61 migraine patients and 60 matched healthy participants. The median plasma copeptin levels in the patients group and control group were 298.25 and 194.35 pg/mL, respectively. Copeptin levels were significantly higher in migraine patients than in the healthy control group. The specificity and sensitivity of copeptin for 249.5 pg/dL cut off value predicting diagnosis of migraine were 67% and 64%, respectively. In addition, TOS and OSI levels were found to be higher and TAS levels were significantly lower in patients with migraine than healthy controls. Plasma copeptin levels are thought to increase in cases of childhood migraine secondary to increased oxidative stress. In the diagnosis of childhood migraine cases, it can be used together with oxidative stress biomarkers such as TAS, TOS and OSI as a complementary parameter.
copeptin 是一种下丘脑应激激素，与精氨酸加压素一起在下丘脑合成，并以等摩尔量从神经垂体循环，可指示个体的应激水平。本研究旨在探讨儿童偏头痛患者的血浆 copeptin 水平。在这项研究中，测量了 61 例偏头痛患者和 60 例匹配健康参与者的血浆样本中的总氧化应激状态（TOS）；总抗氧化状态（TAS）；氧化应激指数（OSI）和 copeptin。患者组和对照组的中位血浆 copeptin 水平分别为 298.25 和 194.35 pg/mL。偏头痛患者的 copeptin 水平明显高于健康对照组。 copeptin 对 249.5 pg/dL 临界值预测偏头痛诊断的特异性和敏感性分别为 67%和 64%。此外，与健康对照组相比，偏头痛患者的 TOS 和 OSI 水平较高，TAS 水平显著降低。血浆 copeptin 水平在儿童偏头痛继发于氧化应激增加的情况下可能会升高。在儿童偏头痛病例的诊断中，它可以与 TAS、TOS 和 OSI 等氧化应激生物标志物一起作为补充参数使用。
