Emergency Department of Çankırı State Hospital, Çankırı, Turkey.
Medical Faculty of Suleyman Demirel University, Emergency Medicine Department, Isparta, Turkey.
Am J Emerg Med. 2020 Sep;38(9):1910-1914. doi: 10.1016/j.ajem.2020.05.009. Epub 2020 May 8.
The purpose of this study was to investigate the clinical use of copeptin to evaluate migraine attacks in the Emergency Department. An additional aim was to detect changes in serum copeptin levels in migraine patients during attack and attack-free periods.
This prospective case-control study included 52 migraine patients and 51 healthy individuals with similar demographic characteristics. Blood samples were collected from migraine patients both in attack and attack-free periods.
The mean copeptin levels in the patients group in the attack and attack-free periods were 689.28 and 576.68 pg/ml, respectively, whereas they were 608.68 pg/ml in the control group. There was a significant difference in the mean copeptin level in the attack period and attack-free periods (p = 0.026). The sensitivity and specificity of copeptin in detecting headache episodes in migraine patients were 58.8% and 60.7%, respectively, at a cut-off value of 388.67 pg/ml.
This is the first study to investigate the diagnostic efficacy of serum copeptin levels in migraine patients. Although the diagnostic efficacy of serum copeptin levels for migraines was unsatisfactory, it could be helpful at management of migraine patients in ED.
本研究旨在探讨加压素原（copeptin）在急诊科评估偏头痛发作中的临床应用。另一个目的是检测偏头痛患者在发作期和无发作期血清 copeptin 水平的变化。
这项前瞻性病例对照研究纳入了 52 名偏头痛患者和 51 名具有相似人口统计学特征的健康对照者。采集偏头痛患者在发作期和无发作期的血样。
发作期和无发作期患者组的平均 copeptin 水平分别为 689.28pg/ml 和 576.68pg/ml，而对照组为 608.68pg/ml。发作期和无发作期的平均 copeptin 水平有显著差异（p=0.026）。以 388.67pg/ml 为 cutoff 值，copeptin 检测偏头痛患者头痛发作的灵敏度和特异度分别为 58.8%和 60.7%。
这是首个研究偏头痛患者血清 copeptin 水平诊断效能的研究。尽管血清 copeptin 水平对偏头痛的诊断效能并不令人满意，但它可能有助于急诊科偏头痛患者的管理。
