Department of Biological and Medical Sciences, Oxford Brookes University , Oxford, UK.
GReD, CNRS, INSERM, Université Clermont Auvergne , Clermont-Ferrand, France.
Nucleus. 2020 Dec;11(1):347-363. doi: 10.1080/19491034.2020.1838697.
In this review, we explore recent advances in knowledge of the structure and dynamics of the plant nuclear envelope. As a paradigm, we focused our attention on the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, a structurally conserved bridging complex comprising SUN domain proteins in the inner nuclear membrane and KASH domain proteins in the outer nuclear membrane. Studies have revealed that this bridging complex has multiple functions with structural roles in positioning the nucleus within the cell, conveying signals across the membrane and organizing chromatin in the 3D nuclear space with impact on gene transcription. We also provide an up-to-date survey in nuclear dynamics research achieved so far in the model plant that highlights its potential impact on several key plant functions such as growth, seed maturation and germination, reproduction and response to biotic and abiotic stress. Finally, we bring evidences that most of the constituents of the LINC Complex and associated components are, with some specificities, conserved in monocot and dicot crop species and are displaying very similar functions to those described for . This leads us to suggest that a better knowledge of this system and a better account of its potential applications will in the future enhance the resilience and productivity of crop plants.
在这篇综述中，我们探讨了植物核膜结构和动力学的最新研究进展。作为范例，我们重点关注核骨架与核纤层连接蛋白（LINC）复合物，这是一种结构保守的桥接复合物，由核内膜中的 SUN 结构域蛋白和核外膜中的 KASH 结构域蛋白组成。研究表明，这种桥接复合物具有多种功能，在核定位、跨膜信号传递以及三维核空间染色质组织方面具有结构作用，从而影响基因转录。我们还提供了迄今为止在模式植物中进行的核动态研究的最新调查，强调了其对植物生长、种子成熟和萌发、繁殖以及对生物和非生物胁迫反应等几个关键功能的潜在影响。最后，我们提供了证据表明，LINC 复合物的大多数组成部分及其相关成分在单子叶和双子叶作物物种中具有一定的特异性，并且具有与描述的 类似的功能。这使我们得出结论，更好地了解这个系统并充分利用其潜在应用，将有助于提高作物的抗逆性和生产力。
