Department of Environmental and Life Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan.
J Plant Res. 2020 Jul;133(4):449-455. doi: 10.1007/s10265-020-01177-0. Epub 2020 Mar 13.
Nuclear pore complexes (NPCs) are large multi-protein complexes that control bidirectional trafficking of macromolecules between the nucleus and cytoplasm. This trafficking is highly regulated and participates in a considerably broader range of cellular activities, including defense responses against pathogens in plants. Recently, NPC is emerging as a platform to physically associate the underlying chromatin with the nuclear periphery, thus regulating chromatin structure and gene expression. For instance, NPC components have been shown to promote the formation of specific genomics loops, which is linked to transcriptional memory for rapid reactivation of genes. With newly developed techniques and tools, our insight in this area has been substantially advanced. This review summarizes recent works on the molecular function of NPC machinery as hubs for transcriptional regulation and compares systems between plant and non-plant organisms.
核孔复合体（NPC）是一种大型的多蛋白复合物，控制着核质与细胞质之间的大分子物质的双向运输。这种运输受到高度调控，参与了更广泛的细胞活动，包括植物对病原体的防御反应。最近，NPC 作为一个平台，将潜在的染色质与核周联系起来，从而调节染色质结构和基因表达。例如，已经表明 NPC 成分促进了特定基因组环的形成，这与基因的快速重新激活的转录记忆有关。随着新技术和工具的发展，我们在这一领域的认识有了实质性的进展。这篇综述总结了 NPC 机械作为转录调控枢纽的分子功能的最新研究进展，并比较了植物和非植物生物之间的系统。
