Yi Meng, Dai Shuchang, Fang Lin, Pan Bo, Fan Bin, Pan Yiming, Liu Zhong
Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Peking Union Medical College, Chengdu 610052, China.
China Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences, Chengdu 610052, China.
Pathogens. 2025 Mar 21;14(4):301. doi: 10.3390/pathogens14040301.
Occult hepatitis B infection (OBI) is a serious public health issue. Although a number of effective hepatitis B vaccines are available, hepatitis B still poses a threat to global public health. Patients with OBI are usually asymptomatic, but there may be active HBV DNA present in their blood, leading to the risk of virus transmission during blood transfusions or organ transplantation, constituting a hazard to the health of recipients and increasing the risk of liver cirrhosis and liver cancer. Although China has progressed in the development of blood-screening technology, OBI is still a significant hidden danger to blood transfusion safety. Therefore, in blood screening and blood transfusion, strengthening the monitoring and management of OBI is crucial to ensure blood safety and protect public health.
隐匿性乙型肝炎感染（OBI）是一个严重的公共卫生问题。尽管有多种有效的乙型肝炎疫苗，但乙型肝炎仍然对全球公共卫生构成威胁。OBI患者通常没有症状，但他们的血液中可能存在活跃的乙肝病毒DNA，这导致在输血或器官移植过程中有病毒传播的风险，对受者的健康构成危害，并增加肝硬化和肝癌的风险。尽管中国在血液筛查技术的发展方面取得了进展，但OBI仍然是输血安全的一个重大隐患。因此，在血液筛查和输血中，加强对OBI的监测和管理对于确保血液安全和保护公众健康至关重要。
