De Arun Kumar, Sawhney Sneha, Mondal Samiran, Ponraj Perumal, Ravi Sanjay Kumar, Sarkar Gopal, Banik Santanu, Malakar Dhruba, Muniswamy Kangayan, Kumar Ashish, Tripathi Arvind Kumar, Bera Asit Kumar, Bhattacharya Debasis
Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair 744101, India.
Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India.
Animals (Basel). 2020 Dec 7;10(12):2312. doi: 10.3390/ani10122312.
The burrowing mite causes scabies in humans or mange in animals. It infests a wide range of mammalian species including livestock, companion animals, wild animals, and humans. Differential diagnosis of varieties is key for epidemiological studies and for formulation of an eradication program. Host-parasite interaction at the systemic level is very important to understand the pathogenicity of the mite. This communication deals with the preliminary report on the genetic characterization of from India. Moreover, the effect of infestation on host physiology with special emphasis on serum biochemical parameters, lipid profile, oxidant/antioxidant balance, stress parameters, and immune responses were evaluated in a porcine model. Cytochrome C oxidase 1 and voltage-sensitive sodium channel based phylogenetic study could distinguish human and animals isolates but could not distinguish host or geographical specific isolates belonging to animal origin. An absence of host-specific cluster among animal isolates argues against the hypothesis of delineating as per host origin. Elevated levels of markers of liver function such as albumin, AST, ALT, ALP, and LDH in infested animals indicated impaired liver function in infested animals. infestation induced atherogenic dyslipidemia indicated by elevated levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides, and a decreased level of high-density lipoprotein cholesterol. Oxidative stress in infested animals was indicated by a high level of nitric oxide and serum MDA as oxidative stress markers and low antioxidant capacity. triggered stress response and elevated levels of serum cortisol and heat shock proteins were recorded in infested animals. infestation increased the serum concentration of immunoglobulins and was associated with up-regulation of IL-2, IFN-γ, IL-1β, and IL-4 indicating both Th1 and Th2 response. The results of the study will be helpful for a better understanding of host-parasite interaction at the systemic level in crusted scabies in pigs.
疥螨可导致人类患疥疮或动物患疥癣。它感染多种哺乳动物，包括家畜、伴侣动物、野生动物和人类。区分不同种类对于流行病学研究和制定根除计划至关重要。在系统水平上了解宿主与寄生虫的相互作用对于理解螨虫的致病性非常重要。本通讯涉及来自印度的[具体名称未给出]的遗传特征的初步报告。此外，在猪模型中评估了[具体名称未给出]感染对宿主生理的影响，特别强调了血清生化参数、血脂谱、氧化/抗氧化平衡、应激参数和免疫反应。基于细胞色素C氧化酶1和电压敏感性钠通道的系统发育研究可以区分人类和动物分离株，但无法区分动物来源的宿主或地理特异性分离株。动物分离株中缺乏宿主特异性聚类，这与根据宿主来源划分[具体名称未给出]的假设相悖。受感染动物中肝功能标志物如白蛋白、谷草转氨酶、谷丙转氨酶、碱性磷酸酶和乳酸脱氢酶水平升高，表明受感染动物肝功能受损。[具体名称未给出]感染导致动脉粥样硬化性血脂异常，表现为总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平升高，高密度脂蛋白胆固醇水平降低。受感染动物的氧化应激表现为一氧化氮和血清丙二醛水平升高作为氧化应激标志物，抗氧化能力降低。[具体名称未给出]引发应激反应，受感染动物血清皮质醇和热休克蛋白水平升高。[具体名称未给出]感染增加了血清免疫球蛋白浓度，并与白细胞介素-2、干扰素-γ、白细胞介素-1β和白细胞介素-4的上调有关，表明同时存在Th1和Th2反应。该研究结果将有助于更好地理解猪结痂性疥疮在系统水平上的宿主-寄生虫相互作用。
