Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Department of Physical Education and Sport Science, Faculty of Human Science, University of Neyshabur, Neyshabur, Iran.
Environ Health. 2020 Dec 9;19(1):131. doi: 10.1186/s12940-020-00682-y.
Preconception exposure to air pollution has been associated with glucose tolerance during pregnancy. However, the evidence in low and middle-income countries (LMICs) is under debate yet. Therefore, this study aimed to assess the relationship between exposure to ambient particulate matter (PM) and traffic indicators with glucose tolerance in healthy pregnant women in Sabzevar, Iran (2019).
Two-hundred and fifty healthy pregnant women with singleton pregnancies and 24-26 weeks of gestations participated in our study. Land use regression (LUR) models were applied to estimate the annual mean of PM, PM and PM at the residential address. Traffic indicators, including proximity of women to major roads as well as total streets length in 100, 300 and 500 m buffers around the home were calculated using the street map of Sabzevar. The oral glucose tolerance test (OGTT) was used to assess glucose tolerance during pregnancy. Multiple linear regression adjusted for relevant covariates was used to estimate the association of fasting blood glucose (FBG), 1-h and 2-h post-load glucose with PMs and traffic indicators.
Exposure to PM, PM and PM was significantly associated with higher FBG concentration. Higher total streets length in a 100 m buffer was associated with higher FBG and 1-h glucose concentrations. An interquartile range (IQR) increase in proximity to major roads was associated with a decrease of - 3.29 mg/dL (95% confidence interval (CI): - 4.35, - 2.23, P-value < 0.01) in FBG level and - 3.65 mg/dL (95% CI, - 7.01, - 0.28, P-value = 0.03) decrease in 1-h post-load glucose.
We found that higher preconception exposure to air pollution was associated with higher FBG and 1-h glucose concentrations during pregnancy.
孕前接触空气污染与孕期血糖耐量有关。然而，在中低收入国家（LMICs）的证据仍存在争议。因此，本研究旨在评估伊朗萨布泽瓦尔（2019 年）健康孕妇暴露于环境颗粒物（PM）和交通指标与血糖耐量的关系。
本研究纳入了 250 名单胎妊娠且孕周为 24-26 周的健康孕妇。应用基于土地利用的回归模型（LUR）来估计其住址处的年平均 PM、PM和 PM浓度。使用萨布泽瓦尔的街道地图计算了与女性居住地距离主干道的远近以及 100、300 和 500 m 缓冲区的总街道长度等交通指标。采用口服葡萄糖耐量试验（OGTT）评估孕妇孕期的血糖耐量。采用多元线性回归模型，调整相关协变量后，评估了 FBG、1 小时和 2 小时负荷后血糖与 PMs 和交通指标的关系。
PM、PM和 PM暴露与 FBG 浓度升高显著相关。100 m 缓冲区的总街道长度增加与 FBG 和 1 小时血糖浓度升高相关。与主干道距离的四分位间距（IQR）增加与 FBG 水平降低-3.29mg/dL（95%置信区间（CI）：-4.35，-2.23，P 值<0.01）和 1 小时负荷后血糖降低-3.65mg/dL（95% CI：-7.01，-0.28，P 值=0.03）相关。
我们发现，孕前暴露于较高浓度的空气污染与孕期 FBG 和 1 小时血糖浓度升高有关。
