Ramírez-Ramos A, Recavarren-Arce S, León-Barúa R, Gilman R, Spira W, Watanabe-Yamamoto J, Garrido-Klinge G, Cok-García J, Zevallos-Coronado E, Rodríguez-Ulloa C
Universidad Peruana Cayetano Heredia.
Arq Gastroenterol. 1987 Jan-Mar;24(1):10-5.
After the initial report of Marshall and Warren, several publications have also demonstrated the presence of pyloric campylobacter in an elevated percentage of cases of chronic gastritis and peptic ulcer. We present our experience studying 672 patients examined by esophagogastroduodenoscopy after referral to clinical because of upper gastrointestinal symptoms. We used an Olympus GIF-K2 panendoscope taking two biopsies from the gastric antrum. Specimens were stained with hematoxilin-eosin and silver. In our experience these methods have given us the best results in detecting this bacteria. Diagnosis of gastric and duodenal ulcer was made by endoscopic criteria and chronic gastritis diagnosed by histology. Chronic gastritis was categorized into active and inactive based in the invasion of polymorphonuclear into mucosa. We have also quantitated damage of the mucin producing cells as well as the degree of bacterial colonization. We have found pyloric campylobacter in 91.8% of patients suffering from chronic active gastritis, 72.7% of patients with diagnosis of gastric ulcer and 84.2% of cases of duodenal ulcer. Our results agree with the ones reported by other authors. We conclude that pyloric campylobacter is not an opportunist microorganism within the stomach because it produces inflammatory changes as well as damage of the mucin producing cells. Its presence may play some role in the etiology of gastritis and peptic ulcer disease.
在马歇尔和沃伦最初发表报告之后，也有几篇文献表明，在慢性胃炎和消化性溃疡病例中，幽门弯曲菌的检出率有所升高。我们介绍了对672例因上消化道症状转诊至临床后接受食管胃十二指肠镜检查的患者的研究经验。我们使用奥林巴斯GIF-K2型通用内窥镜，从胃窦取两块活检组织。标本用苏木精-伊红和银染色。根据我们的经验，这些方法在检测这种细菌方面效果最佳。胃溃疡和十二指肠溃疡通过内镜标准诊断，慢性胃炎通过组织学诊断。慢性胃炎根据多形核白细胞侵入黏膜的情况分为活动期和非活动期。我们还对黏蛋白产生细胞的损伤以及细菌定植程度进行了定量分析。我们发现，在患有慢性活动性胃炎的患者中，幽门弯曲菌检出率为91.8%，胃溃疡患者中为72.7%，十二指肠溃疡患者中为84.2%。我们的结果与其他作者报告的结果一致。我们得出结论，幽门弯曲菌在胃内不是一种机会性微生物，因为它会引起炎症变化以及黏蛋白产生细胞的损伤。它的存在可能在胃炎和消化性溃疡病的病因学中起一定作用。
