Kovacic P, Ames J R, Lumme P, Elo H, Cox O, Jackson H, Rivera L A, Ramirez L, Ryan M D
Department of Chemistry, University of Wisconsin-Milwaukee 53201.
Anticancer Drug Des. 1986 Nov;1(3):197-214.
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm. Electrochemical studies were performed with some of the main types of agents: iminium ions (adenine iminium from alkylating species, iminium metabolite of 6-mercaptopurine, nitidine, other polynuclear iminiums) and metal complexes (Pt(II)diaquodiammine-guanosine, copper salicylaldoximes). Reduction potentials ranged from -0.4 to -1.2 V. Literature data for quinones are presented and radiation is discussed. Based on the theoretical framework, a rationale is offered for the carcinogen-anti-cancer paradox and the role of antioxidants.
有人提出抗癌药物一般通过电荷转移发挥作用，导致形成有毒的氧自由基，从而破坏肿瘤。对一些主要类型的药物进行了电化学研究：亚胺离子（烷基化物质产生的腺嘌呤亚胺、6-巯基嘌呤的亚胺代谢物、两面针碱、其他多核亚胺）和金属配合物（Pt(II)二水二氨-鸟苷、铜水杨醛肟）。还原电位范围为-0.4至-1.2V。列出了醌类的文献数据并讨论了辐射。基于该理论框架，对致癌物-抗癌悖论和抗氧化剂的作用给出了一种解释。
