未筛查人群的结直肠癌结局：性别及其他决定因素对癌症分期的影响
The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage.
作者信息
Alyabsi Mesnad, Sabatin Fouad, Jazieh Abdul Rahman
机构信息
Population Health Research Section, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
出版信息
Cancer Manag Res. 2020 Dec 1;12:12319-12327. doi: 10.2147/CMAR.S268823. eCollection 2020.
BACKGROUND
In Saudi Arabia, there is no population-based colorectal cancer (CRC) screening, and more than two-thirds of patients are diagnosed with a late stage. We assessed the association between sex and distant metastasis CRC and hypothesize that females, younger age, non-married, and patients with colon cancer would present with metastatic tumors.
PATIENTS AND METHODS
The retrospective cohort study used data from the Ministry of National Guard Cancer Registry. Logistic regression was used to assess the association between sex and metastatic CRC adjusting for patient covariates. In a sensitivity analysis, the association between sex and late-stage CRC was evaluated.
RESULTS
A total of 1016 CRC patients met the eligibility criteria, with 37.59% of females and 30.26% of males diagnosed with metastatic CRC. After adjusting for marital status, grade, and morphology, females were 20% more likely than males to present with a metastatic tumor 1.20 (95% CI, 1.04-1.38).
CONCLUSION
Although the entire Saudi population would benefit from CRC screening, women may benefit the most from targeted screening.
背景
在沙特阿拉伯，尚无基于人群的结直肠癌（CRC）筛查，超过三分之二的患者在晚期才被诊断出来。我们评估了性别与远处转移结直肠癌之间的关联，并假设女性、年轻、未婚以及结肠癌患者会出现转移性肿瘤。
患者与方法
这项回顾性队列研究使用了国民卫队癌症登记处的数据。采用逻辑回归分析评估性别与转移性结直肠癌之间的关联，并对患者协变量进行校正。在敏感性分析中，评估了性别与晚期结直肠癌之间的关联。
结果
共有1016例CRC患者符合纳入标准，其中37.59%的女性和30.26%的男性被诊断为转移性CRC。在对婚姻状况、分级和形态进行校正后，女性出现转移性肿瘤的可能性比男性高20%，比值比为1.20（95%置信区间，1.04 - 1.38）。
结论
虽然整个沙特人群都将从CRC筛查中受益，但女性可能从针对性筛查中获益最大。
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