Alyabsi Mesnad, Algarni Mohammed, Alshammari Kanan
Population Health Research Section, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Front Oncol. 2021 Sep 9;11:730689. doi: 10.3389/fonc.2021.730689. eCollection 2021.
Early-onset (<50 years old) colorectal cancer (CRC) has been increasing worldwide and is associated with poor outcomes. Over 85% of the Saudi population are <50 years old, which put them at heightened risk of early-onset CRC. No study assessed the trends in CRC incidence rates among the Saudis. The Joinpoint Regression software by the Surveillance, Epidemiology, and End Results (SEER) program was used to estimate the magnitude and direction of CRC incidence trends by age and gender. The annual percentage change (APC) and the average annual percentage change (AAPC) between 2001 and 2016 were computed. In a sensitivity analysis, we also assessed trends using various age groups. Between 2001 and 2016, the early-onset CRC incidence (per 10) increased from 1.32 (95% CI: 1.11, 1.54) to 2.02 (95% CI: 1.83, 2.22) with AAPC (2.6, 95% CI: -0.4, 5.7). At same period, the late-onset incidence increased from 3.54 (95% CI: 3.10, 3.97) to 9.14 (95% CI: 8.62, 9.66) with AAPC (6.1, 95% CI: 3.5, 8.8). Among early-onset CRC patients, age 40-49 has the highest rates and women in this age group has higher rate than men. Our national data showed a gradual increase in CRC incidence rates, which reflect the global concern of early-onset CRC. Further research is needed to understand the etiology of early-onset CRC. Primary health care providers must be alerted about the increasing rate of early-onset CRC. To reduce the future burden of the disease, initiating CRC screening before age 50 is warranted.
早发性（<50岁）结直肠癌（CRC）在全球范围内呈上升趋势，且与不良预后相关。沙特超过85%的人口年龄<50岁，这使他们患早发性结直肠癌的风险增加。尚无研究评估沙特人结直肠癌发病率的趋势。利用监测、流行病学和最终结果（SEER）项目的Joinpoint回归软件，按年龄和性别估计结直肠癌发病率趋势的幅度和方向。计算了2001年至2016年期间的年度百分比变化（APC）和平均年度百分比变化（AAPC）。在敏感性分析中，我们还使用不同年龄组评估了趋势。2001年至2下载文档到电脑，查找使用更方便
16年期间，早发性结直肠癌发病率（每10万人）从1.32（95%CI：1.11，1.54）增至2.02（95%CI：1.83，2.22），AAPC为2.6（95%CI：-0.4，5.7）。同期，晚发性发病率从3.54（95%CI：3.10，3.97）增至9.14（95%CI：8.62，9.66），AAPC为6.1（95%CI：3.5，8.8）。在早发性结直肠癌患者中，40 - 49岁发病率最高，该年龄组女性发病率高于男性。我们的国家数据显示结直肠癌发病率逐渐上升，这反映了全球对早发性结直肠癌的关注。需要进一步研究以了解早发性结直肠癌的病因。必须提醒初级卫生保健提供者注意早发性结直肠癌发病率的上升。为减轻该疾病未来的负担，有必要在50岁之前启动结直肠癌筛查。
