Basudan Ahmed M, Basuwdan Abdulrahman Mohammed, Abudawood Manal, Farzan Raed, Alfhili Mohammad A
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 14611, Saudi Arabia.
Life (Basel). 2023 Nov 11;13(11):2198. doi: 10.3390/life13112198.
Colorectal cancer (CRC) is the commonest cancer in Saudi males and the third most common in Saudi females. Although CRC represents a major public health challenge, the resources to evaluate its burden are inadequate. This study aims to elucidate the magnitude of CRC incidence trends in the Saudi population by age, gender, and administrative region. Data for multiple incidence measures were analyzed from the Saudi Cancer Registry (SCR) retrospectively from 2001 to 2018. Temporal trends were further analyzed by age group, gender, administrative region, and globally using joinpoint regression analysis. The number of CRC cases climbed by 335.6% and the disease increased by 56.4% to comprise 12.2% of all cancers cases. The age-standardized incidence rate (ASR) increased by 152% overall, and the median age at diagnosis peaked at 60 and 58 years for males and females, respectively. Riyadh and the Eastern Region had the highest ASR for both genders, peaking at 21.8 and 19.2 for males and 17.4 and 16.5 for females per 100 K population. Our prediction model identified growing trends with annual percentage changes (APCs) of 4.59% in males (CI: 3.1-6.1) and 3.91% among females (CI: 2.4-5.5). Males above 75 years had the highest APC (7.9%, CI: 5.3-10.7), whereas the highest APC among females was found in the age group 70-74 (5.4%, CI: 2.8-8). Globally, APC was the highest for both genders compared to selected countries. CRC incidence is increasing alarmingly in Saudi Arabia and is projected to continue. There is a need for better screening strategies, preventative measures, and awareness-building.
结直肠癌（CRC）是沙特男性中最常见的癌症，在沙特女性中位列第三。尽管结直肠癌是一项重大的公共卫生挑战，但评估其负担的资源却不足。本研究旨在按年龄、性别和行政区阐明沙特人群中结直肠癌发病率趋势的规模。对沙特癌症登记处（SCR）2001年至2018年的多发病率测量数据进行了回顾性分析。通过年龄组、性别、行政区，并在全球范围内使用连接点回归分析进一步分析了时间趋势。结直肠癌病例数攀升了335.6%，该疾病增加了56.4%，占所有癌症病例的12.2%。总体年龄标准化发病率（ASR）上升了152%，男性和女性的诊断中位年龄分别在60岁和58岁达到峰值。利雅得和东部地区的男女ASR最高，男性每10万人口分别达到21.8和19.2，女性为17.4和16.5。我们的预测模型确定了增长趋势，男性的年百分比变化（APC）为4.59%（置信区间：3.1 - 6.1），女性为3.91%（置信区间：2.4 - 5.5）。75岁以上男性的APC最高（7.9%，置信区间：5.3 - 10.7），而女性中APC最高的是70 - 74岁年龄组（5.4%，置信区间：2.8 - 8）。在全球范围内，与选定国家相比，男女的APC都是最高的。沙特阿拉伯的结直肠癌发病率正在惊人地上升，预计还将持续。需要更好的筛查策略、预防措施和提高认识。
