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微小RNA-361-3p通过Wnt/β-连环蛋白信号通路抑制淋巴瘤进展。

MicroRNA-361-3p Inhibit the Progression of Lymphoma by the Wnt/β-Catenin Signaling Pathway.

作者信息

Zhou Hui, Tang Huifeng, Li Ning, Chen Hang, Chen Xiaohui, Gu Lei, Zhang Liang, Tian Guoyan, Tao Diehong

机构信息

Department of Hematology and Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, People's Republic of China.

Hematology Department, Tongde Hospital, Zhejiang Province, Hangzhou 310003, People's Republic of China.

出版信息

Cancer Manag Res. 2020 Dec 2;12:12375-12384. doi: 10.2147/CMAR.S270374. eCollection 2020.

DOI:10.2147/CMAR.S270374
PMID:33299350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7721010/
Abstract

BACKGROUND

MicroRNA is involved in the development of lymphoma. It is reported that miR-361-3p has a tumor inhibitory effect, but its role in lymphoma is still unclear. The purpose of this study is to examine whether miR-361-3p can inhibit the development of lymphoma and further explore the related potential mechanism.

METHODS

In this study, we first analyzed the biological function of miR-361-3p in transfected Raji that mimicked miRNA. We also analyzed the biological function of the whole population in stably expressed miR-361-3p transgenic cells. Next, we conducted a complete micro-gene network to test the genetic profile of differential expression of stable gene-modified cells.

RESULTS

We found that miR-361-3p expression was often reduced in lymphoma cell lines. Cellular assays have shown a significant role in inhibiting the growth of miR-361-3p by inhibiting lymphoma proliferation and migration, and severely inhibiting the Wnt/β-catenin series protein signal. Bioinformatics analysis shows that Wnt10A is a new target of miR-361-3p, which is confirmed by our mechanism research. It is confirmed that restoring Wnt10A can reduce the tumor inhibition of Wnt/β-catenin during lymphoma progression and restore the normal signal of Wnt/β-catenin series proteins.

DISCUSSION

Our data indicate that miR-361-3p inhibits the Wnt/β-catenin protein signal by locking Wnt10A, which is an important factor in inhibiting the tumor in the pathogenesis of lymphoma. The miR-361-3p/Wnt10A axis may be a promising target for the treatment of lymphoma.

摘要

背景

微小RNA参与淋巴瘤的发展。据报道，miR-361-3p具有肿瘤抑制作用，但其在淋巴瘤中的作用仍不清楚。本研究的目的是检测miR-361-3p是否能抑制淋巴瘤的发展，并进一步探索相关的潜在机制。

方法

在本研究中，我们首先分析了模拟miRNA的转染Raji中miR-361-3p的生物学功能。我们还分析了稳定表达miR-361-3p转基因细胞中全群体的生物学功能。接下来，我们进行了完整的微基因网络以测试稳定基因修饰细胞差异表达的基因谱。

结果

我们发现miR-361-3p在淋巴瘤细胞系中的表达常常降低。细胞实验表明，miR-361-3p通过抑制淋巴瘤增殖和迁移对其生长具有显著抑制作用，并严重抑制Wnt/β-连环蛋白系列蛋白信号。生物信息学分析表明，Wnt10A是miR-361-3p的一个新靶点，这在我们的机制研究中得到了证实。证实恢复Wnt10A可降低淋巴瘤进展过程中Wnt/β-连环蛋白的肿瘤抑制作用，并恢复Wnt/β-连环蛋白系列蛋白的正常信号。

讨论

我们的数据表明，miR-361-3p通过锁定Wnt10A抑制Wnt/β-连环蛋白蛋白信号，这是淋巴瘤发病机制中抑制肿瘤的一个重要因素。miR-361-3p/Wnt10A轴可能是治疗淋巴瘤的一个有前景的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/9d6ed71d1b61/CMAR-12-12375-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/cc49e86db4ae/CMAR-12-12375-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/e98ecfbf9645/CMAR-12-12375-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/2f251e8b20f8/CMAR-12-12375-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/5c2628f54995/CMAR-12-12375-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/9d6f1088b2cc/CMAR-12-12375-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/45ea5b583b26/CMAR-12-12375-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/fbaedc71619d/CMAR-12-12375-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/9d6ed71d1b61/CMAR-12-12375-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/cc49e86db4ae/CMAR-12-12375-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/e98ecfbf9645/CMAR-12-12375-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/2f251e8b20f8/CMAR-12-12375-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/5c2628f54995/CMAR-12-12375-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/9d6f1088b2cc/CMAR-12-12375-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/45ea5b583b26/CMAR-12-12375-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/fbaedc71619d/CMAR-12-12375-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa65/7721010/9d6ed71d1b61/CMAR-12-12375-g0008.jpg

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