Division of Nephrology, Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Dis Markers. 2020 Nov 25;2020:5514145. doi: 10.1155/2020/5514145. eCollection 2020.
Tumor necrosis factor- (TNF-) is a proinflammatory factor involved in the pathogenesis of immunoglobulin A vasculitis (IgAV). The association between serum TNF- and disease severity in adult patients with IgAV nephritis (IgAV-N) has been inadequately evaluated.
Serum TNF- was measured by chemiluminescence immunoassay in 53 renal biopsy-proved IgAV-N patients, 53 healthy controls, and 53 IgA nephropathy (IgAN) patients. The correlations of clinicopathologic parameters of IgAV-N patients with serum TNF- were analyzed.
In this cross-sectional study, the median age of IgAV-N patients was 29 (25-37) years, and 67.9% were female. Serum TNF- was significantly higher in the IgAV-N group than in the healthy group [7.4 (5.7-9.4) pg/mL 5.9 (5.0, 7.1) pg/mL, = 0.001], but comparable with sex, age, and estimated glomerular filtration rate (eGFR) grade-matched IgAN patients. Serum creatinine ( = 0.006) and serum cystatin C ( = 0.001) were positively correlated with serum TNF- level, while albumin ( = 0.014) and eGFR ( = 0.021) were negatively correlated with serum TNF- level. Multivariate linear regression analysis revealed that eGFR ( = 0.007) was an independent clinical predictor of serum TNF-. Patients with higher pathological classification grade also had higher serum TNF-.
Serum TNF- is associated with renal function and the pathological classification of adult patients with IgAV-N. TNF- is a potential biomarker for the assessment of IgAV-N severity.
肿瘤坏死因子-（TNF-）是一种参与免疫球蛋白 A 血管炎（IgAV）发病机制的促炎因子。血清 TNF-与成人 IgAV 肾炎（IgAV-N）患者疾病严重程度之间的关系尚未得到充分评估。
采用化学发光免疫分析法检测 53 例肾活检证实的 IgAV-N 患者、53 名健康对照者和 53 例 IgA 肾病（IgAN）患者的血清 TNF-。分析 IgAV-N 患者的临床病理参数与血清 TNF-的相关性。
在这项横断面研究中，IgAV-N 患者的中位年龄为 29（25-37）岁，67.9%为女性。与健康对照组相比，IgAV-N 组血清 TNF-显著升高[7.4（5.7-9.4）pg/mL 5.9（5.0, 7.1）pg/mL， = 0.001]，但与性别、年龄和估计肾小球滤过率（eGFR）分级匹配的 IgAN 患者相当。血清肌酐（ = 0.006）和血清胱抑素 C（ = 0.001）与血清 TNF-水平呈正相关，而白蛋白（ = 0.014）和 eGFR（ = 0.021）与血清 TNF-水平呈负相关。多变量线性回归分析显示，eGFR（ = 0.007）是血清 TNF-的独立临床预测因子。病理分级较高的患者血清 TNF-水平也较高。
血清 TNF-与成人 IgAV-N 患者的肾功能和病理分级有关。TNF-可能是评估 IgAV-N 严重程度的潜在生物标志物。
