Farhat Grace, Malla Jhama, Vadher Jay, Al-Dujaili Emad A S
Faculty of Health and Education, Manchester Metropolitan University, Manchester M15 6BG, UK.
Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7YH, UK.
Nutrients. 2025 Apr 1;17(7):1235. doi: 10.3390/nu17071235.
: Chronic inflammation increases morbidity in older adults and significantly impacts healthy ageing. Pomegranate extract (PE), rich in polyphenols, has been suggested to reduce inflammation and could prevent cardiovascular disease. However, there is limited research examining the potential of PE in disease prevention in ageing. : A two-arm double-blind parallel trial was conducted, in which participants received either placebo capsules (maltodextrin) or pomegranate extract (740 mg) daily for 12 weeks. At baseline, week 6, and week 12, anthropometric measurements, blood pressure, and blood samples were collected. Serum inflammatory markers (IL-6, IL-1-α, IL1-β, IL-2, TNF-α, CRP and PAI-1), fasting blood glucose, and lipid levels were also measured. : A total of 86 participants met the eligibility criteria, with 76 completing the trial. A significant interaction between treatment and time was observed for the IL-6 ( = 0.02) and IL1-β ( = 0.05) levels, with both parameters significantly decreasing in the PE group. CRP and TNF-α showed a downward trend in the PE group, but it was not statistically significant ( > 0.05). Systolic blood pressure significantly decreased in the PE group (by 5.22 ± 1.26 mmHg (SE), = 0.04), indicating potential clinical relevance, with diastolic blood pressure showing a similar downward trend (2.94 ± 1.08 mmHg (SE), = 0.3). Despite being apparently healthy with no diagnosed diseases, a substantial number of participants exhibited elevated levels of inflammatory markers and systolic blood pressure. : PE can lower inflammatory markers and blood pressure, which can be high in both normal-weight and overweight older adults, making it a cost-effective measure to promote healthy ageing. Further long-term studies are needed to address the limitations of this 3-month study, including the overrepresentation of normal-weight participants, and to gain a better understanding of the impact of weight on the above-mentioned outcomes.
慢性炎症会增加老年人的发病率，并对健康老龄化产生重大影响。富含多酚的石榴提取物（PE）被认为可以减轻炎症，并预防心血管疾病。然而，关于PE在预防衰老相关疾病方面潜力的研究有限。
开展了一项双臂双盲平行试验，参与者连续12周每天服用安慰剂胶囊（麦芽糊精）或石榴提取物（740毫克）。在基线、第6周和第12周时，收集人体测量数据、血压和血样。还测量了血清炎症标志物（白细胞介素-6、白细胞介素-1-α、白细胞介素-1-β、白细胞介素-2、肿瘤坏死因子-α、C反应蛋白和纤溶酶原激活物抑制剂-1）、空腹血糖和血脂水平。
共有86名参与者符合入选标准，76人完成了试验。观察到白细胞介素-6（P = 0.02）和白细胞介素-1-β（P = 0.05）水平在治疗与时间之间存在显著交互作用，PE组这两个参数均显著下降。C反应蛋白和肿瘤坏死因子-α在PE组呈下降趋势，但无统计学意义（P > 0.05）。PE组收缩压显著下降（5.22±1.26毫米汞柱（标准误），P = 0.04），表明具有潜在临床意义，舒张压也呈类似下降趋势（2.94±1.08毫米汞柱（标准误），P = 0.3）。尽管大量参与者表面健康且无确诊疾病，但仍有相当一部分人的炎症标志物水平和收缩压升高。
PE可以降低炎症标志物和血压，正常体重和超重的老年人中这些指标可能都较高，这使其成为促进健康老龄化的一种经济有效的措施。需要进一步开展长期研究，以解决这项为期3个月研究的局限性，包括正常体重参与者比例过高的问题，并更好地了解体重对上述结果的影响。
